Fibronectin is a critical component of the extracellular matrix and alterations to its structure
will influence cellular behavior. Matrix fibronectin is subjected to both mechanical and …

Toll-like receptors (TLRs) are crucial for our host defense against microbial infections. TLR2
is especially important to fight bacterial infections, as it specifically recognizes bacterial …

Diabetic cardiomyopathy has been known as an important complication of diabetes and
characterized by persistent diastolic dysfunction, resulting in myocardial fibrosis, which is …

Toll-like receptors (TLRs) act as the first line of defense against bacterial and viral
pathogens by initiating critical defense signals upon dimer activation. The contribution of the …

The article discusses the role of cytokines in the regulation of immune responses to
Porphyromonas gingivalis with emphasis on innate immunity. It says that the cytokine …

Broad-spectrum inhibitors of histone deacetylases (HDACs) constrain Toll-like receptor
(TLR)-inducible production of key proinflammatory mediators. Here we investigated HDAC …

Toll‐like receptor‐4 (TLR4) pathways are major contributors to pathological inflammatory
responses induced by tissue damage. NI‐0101 is the first monoclonal antibody (mAb) …

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by
inflammatory cell infiltration, high levels of cytokines, and erosion of cartilage and bone in …

Macrophages are highly plastic immune cells that dynamically integrate microenvironmental
signals to shape their own functional phenotypes, a process known as polarization. Here we …

The manufacture, use and disposal of nanomaterials will result in increased human
exposures to engineered nanoparticles (ENPs), potentially via the lung. ENPs differ …