Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings
T Pap, A Korb-Pap - Nature Reviews Rheumatology, 2015 - nature.com
Cartilage damage is a key feature of degenerative joint disorders—primarily osteoarthritis
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …
Inflammation and epigenetic regulation in osteoarthritis
Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …
recognized that there is a major inflammatory component to this disease. In addition to …
Main and minor types of collagens in the articular cartilage: the role of collagens in repair tissue evaluation in chondral defects
L Alcaide-Ruggiero, V Molina-Hernández… - International Journal of …, 2021 - mdpi.com
Several collagen subtypes have been identified in hyaline articular cartilage. The main and
most abundant collagens are type II, IX and XI collagens. The minor and less abundant …
most abundant collagens are type II, IX and XI collagens. The minor and less abundant …
Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy
P Singh, KB Marcu, MB Goldring… - Annals of the New York …, 2019 - Wiley Online Library
Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …
Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis
S Portal-Nunez, P Esbrit, MJ Alcaraz, R Largo - Biochemical pharmacology, 2016 - Elsevier
Aging is a natural process characterized by the declining ability of the different organs and
tissues to respond to stress, increasing homeostatic imbalance and risk of disease …
tissues to respond to stress, increasing homeostatic imbalance and risk of disease …
Data-driven identification of predictive risk biomarkers for subgroups of osteoarthritis using interpretable machine learning
Osteoarthritis (OA) is increasing in prevalence and has a severe impact on patients' lives.
However, our understanding of biomarkers driving OA risk remains limited. We developed a …
However, our understanding of biomarkers driving OA risk remains limited. We developed a …
The role of genetics and epigenetic regulation in the pathogenesis of osteoarthritis
K Kiełbowski, M Herian, E Bakinowska… - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is progressive disease characterised by cartilage degradation,
subchondral bone remodelling and inflammation of the synovium. The disease is associated …
subchondral bone remodelling and inflammation of the synovium. The disease is associated …
Endoplasmic reticulum stress and unfolded protein response in cartilage pathophysiology; contributing factors to apoptosis and osteoarthritis
Chondrocytes of the growth plate undergo apoptosis during the process of endochondral
ossification, as well as during the progression of osteoarthritis. Although the regulation of …
ossification, as well as during the progression of osteoarthritis. Although the regulation of …
[HTML][HTML] Analysis of genetics and DNA methylation in osteoarthritis: what have we learnt about the disease?
LN Reynard - Seminars in Cell & Developmental Biology, 2017 - Elsevier
Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …
[HTML][HTML] Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis
A Takahashi, MC De Andrés, K Hashimoto, E Itoi… - Osteoarthritis and …, 2015 - Elsevier
Objective To determine whether altered IL8 methylation status is associated with increased
expression of IL8 in human osteoarthritic (OA) chondrocytes. Methods IL8 expression levels …
expression of IL8 in human osteoarthritic (OA) chondrocytes. Methods IL8 expression levels …