Oligonucleotides can be used to modulate gene expression via a range of processes
including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation …

Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically
affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial …

Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has
remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated …

The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase
(G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in …

Proper muscle function constitutes a precondition for good heath and an active lifestyle
during an individual's lifespan and any deviations from normal skeletal muscle development …

Satellite cells, the predominant stem cell population in adult skeletal muscle, are activated in
response to hypertrophic stimuli and give rise to myogenic progenitor cells (MPCs) within …

The genesis of skeletal muscle during embryonic development and postnatal life serves as a
paradigm for stem and progenitor cell maintenance, lineage specification, and terminal …

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules involved in the
regulation of gene expression. They are involved in the fine-tuning of fundamental biological …

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by
progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier …