Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity
PD Davis, LH Elliott, W Harris, CH Hill… - Journal of medicinal …, 1992 - ACS Publications
A hypothetical mode ofinhibition of protein kinase C (PKC) by the natural product
staurosporine has been used as a basis for thedesign of substituted bisindolylmaleimides …
staurosporine has been used as a basis for thedesign of substituted bisindolylmaleimides …
Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction
RA Bit, PD Davis, LH Elliott, W Harris… - Journal of medicinal …, 1993 - ACS Publications
The protein kinase inhibitor staurosporine has been used to design a series of selective
bisindolylmaleimide inhibitors of protein kinase C (PKC). Guided by molecular graphics …
bisindolylmaleimide inhibitors of protein kinase C (PKC). Guided by molecular graphics …
Production of colony-stimulating factor by tumor cells and the factor-mediated induction of suppressor cells.
Y Tsuchiya, M Igarashi, R Suzuki… - Journal of immunology …, 1988 - journals.aai.org
Spleen mononuclear cells of C3H/HeN mice were cultivated with mitomycin C-treated tumor
cells, X5563, MH134, MM48, MM46, and FM3A/R, all of which were of syngeneic origin, in a …
cells, X5563, MH134, MM48, MM46, and FM3A/R, all of which were of syngeneic origin, in a …
Autologous mixed lymphocyte reaction in health and disease states in man
S Gupta - Vox Sanguinis, 1983 - karger.com
In this review are discussed the nature of T cell subsets, defined with monoclonal antibodies,
responding in T-non-T and TT autologous mixed-lymphocyte reactions (AMLR) and antigens …
responding in T-non-T and TT autologous mixed-lymphocyte reactions (AMLR) and antigens …
Defective monocyte production of, and T lymphocyte response to, interleukin-1 in the peripheral blood of patients with systemic lupus erythematosus.
J Alcocer-Varela, A Laffon… - Clinical and …, 1984 - ncbi.nlm.nih.gov
Abstract Interleukin-1 (IL-1) is a monocyte product with diverse amplifying effects on immune
cell reactions. We have studied 16 untreated SLE patients to determine the production of IL …
cell reactions. We have studied 16 untreated SLE patients to determine the production of IL …
A novel conformationally restricted protein kinase C inhibitor, Ro 31-8425, inhibits human neutrophil superoxide generation by soluble, particulate and post-receptor …
RE Muid, MM Dale, PD Davis, LH Elliott, CH Hill… - FEBS letters, 1991 - Elsevier
A novel, bis-indolylmaleimide, Ro 31-8425, bearing a conformationally restricted side chain,
inhibits protein kinase C isolated from rat brain and human neutrophils with a high degree of …
inhibits protein kinase C isolated from rat brain and human neutrophils with a high degree of …
Reactivity of inducer cell subsets and T8-cell activation during the human autologous mixed lymphocyte reaction
PL Romain, C Morimoto, JF Daley, LS Palley… - Clinical Immunology and …, 1984 - Elsevier
To characterize the responding T cells in the autologous mixed lymphocyte reaction (AMLR),
T cells were fractionated into purified subpopulations employing monoclonal antibodies and …
T cells were fractionated into purified subpopulations employing monoclonal antibodies and …
Tumor growth alters T cell and macrophage production of and responsiveness to granulocyte-macrophage colony-stimulating factor: partial dysregulation through …
TM Walker, CJ Burger, KD Elgert - Cellular immunology, 1994 - Elsevier
Tumor growth induces phenotypic and functional changes among splenic T cells and
macrophages (Mφ) that contribute to the immunosuppression observed in tumor-bearing …
macrophages (Mφ) that contribute to the immunosuppression observed in tumor-bearing …
Studies on thyroglobulin-specific suppressor T cell function in autoimmune thyroid disease
H MORI, N HAMADA… - The Journal of Clinical …, 1985 - academic.oup.com
T cell regulation of the generation of thyroglobulin plaque-forming cells (Tg PFC) and protein
A plaque-forming cells (Prot A PFC) was investigated using lymphocytes from patients with …
A plaque-forming cells (Prot A PFC) was investigated using lymphocytes from patients with …
Oral, anti-inflammatory activity of a potent, selective, protein kinase C inhibitor
MJ Mulqueen, D Bradshaw, PD Davis, L Elliott… - Agents and Actions, 1992 - Springer
The protein kinase C family of enzymes is thought to be important in mediating signal
transduction. Ro 31-8830 is a novel, potent inhibitor of protein kinase C, derived from the …
transduction. Ro 31-8830 is a novel, potent inhibitor of protein kinase C, derived from the …