Application of metabolomics in the diagnosis of non-alcoholic fatty liver disease and the treatment of traditional Chinese medicine

M Shao, Y Lu, H Xiang, J Wang, G Ji… - Frontiers in Pharmacology, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease around
the world, and it often coexists with insulin resistance-related diseases including obesity …

Pharmacological evaluation of anti-arthritic potential of terpinen-4-ol using in vitro and in vivo assays

S Aslam, W Younis, MNH Malik, S Jahan… - …, 2022 - Springer
Terpinen 4-ol, a phytochemical is a monoterpene which has been reported for its anti-
inflammatory effect. Present research was planned to check its effect against arthritis through …

Rosuvastatin attenuates rheumatoid arthritis-associated manifestations via modulation of the pro-and anti-inflammatory cytokine network: a combination of in vitro and …

S Qasim, Alamgeer, S Kalsoom, M Shahzad… - ACS …, 2021 - ACS Publications
The current investigation employed rosuvastatin for evaluation as an antiarthritic agent by in
vitro and in vivo studies. In vitro studies comprised egg albumin and bovine serum albumin …

Improving the treatment of bacterial infections caused by multidrug-resistant bacteria through drug repositioning

P Glajzner, A Bernat… - Frontiers in …, 2024 - frontiersin.org
Drug repurposing (repositioning) is a dynamically-developing area in the search for effective
therapy of infectious diseases. Repositioning existing drugs with a well-known …

Attenuation of CFA-induced chronic inflammation by a bicyclic monoterpene fenchone targeting inducible nitric oxide, prostaglandins, C-reactive protein and urea

S Nawaz, HM Irfan, Alamgeer, L Arshad… - Inflammopharmacology, 2023 - Springer
Fenchone (a bicyclic monoterpene) is present in the essential oils of plant species like
Foeniculum vulgare and Peumus boldus and is used to treat GIT disorders. Research …

Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress …

N Nazar, MH Mehmood, R Siddique, MN Faisal - Inflammopharmacology, 2024 - Springer
Medicinal plants play a pivotal role in the prevention of chronic non-communicable diseases
including arthritis. Despite the traditional use of Asparagus dumosus in arthritis, it has not …

Appraisal of the antiarthritic potential of prazosin via inhibition of proinflammatory cytokine TNF-α: a key player in rheumatoid arthritis

S Qasim, Alamgeer, M Saleem, NH Alotaibi… - ACS …, 2021 - ACS Publications
Prazosin, a selective α1 adrenergic receptor antagonist, with documented anti-inflammatory
potential, was evaluated for its antiarthritic efficacy by targeting specifically TNF-α. The …

Linalool: Monoterpene alcohol effectiveness in chronic synovitis through lowering Interleukin-17, spleen and thymus indices

S Nawaz, HM Irfan, M Akram, S Jahan - International …, 2023 - Elsevier
Interleukin-17 has a positive role in the initial induction and late chronic phases of many
inflammatory disorders like arthritis. This cytokine has a strong option for therapeutic …

Enalapril attenuated CFA provoked arthritic manifestation by modulating proinflammatory and anti-inflammatory cytokine network

YH Khan, S Qasim, AM Uttra, NH Alotaibi, AS Alanazi… - Life Sciences, 2023 - Elsevier
Enalapril with documented anti-inflammatory potential was evaluated in current investigation
to explore its anti-arthritic efficacy. For anti-arthritic evaluation of enalapril, CFA-instigated …

[HTML][HTML] Amlodipine alleviates cisplatin-induced nephrotoxicity in rats through gamma-glutamyl transpeptidase (GGT) enzyme inhibition, associated with regulation of …

AA Azouz, EAN Abdel-Razek… - Saudi Pharmaceutical …, 2020 - Elsevier
Background The therapeutic utility of the effective chemotherapeutic agent cisplatin is
hampered by its nephrotoxic effect. We aimed from the current study to examine the possible …