Cellular and molecular evidence of multiple sclerosis diagnosis and treatment challenges

Z Khan, GD Gupta, S Mehan - Journal of clinical medicine, 2023 - mdpi.com
Multiple sclerosis (MS) is a chronic autoimmune disease that impacts the central nervous
system and can result in disability. Although the prevalence of MS has increased in India …

Multiple sclerosis: management issues during pregnancy

S Ferrero, S Pretta, N Ragni - European journal of obstetrics & gynecology …, 2004 - Elsevier
Care of pregnant women with multiple sclerosis (MS) is challenging because of the multiple
physiological changes associated with pregnancy and the need to consider the impact of …

Estrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation

I Mohammad, I Starskaia, T Nagy, J Guo, E Yatkin… - Science …, 2018 - science.org
It has long been appreciated that most autoimmune disorders are characterized by
increased prevalence in females, suggesting a potential role for sex hormones in the …

Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy

JB Engler, N Kursawe, ME Solano… - Proceedings of the …, 2017 - National Acad Sciences
Pregnancy is one of the strongest inducers of immunological tolerance. Disease activity of
many autoimmune diseases including multiple sclerosis (MS) is temporarily suppressed by …

Psychological stress and the subsequent appearance of new brain MRI lesions in MS

DC Mohr, DE Goodkin, P Bacchetti, AC Boudewyn… - Neurology, 2000 - AAN Enterprises
Objective: To examine the relationship between stressful life events and psychological
distress, and the subsequent development of gadolinium-enhancing (Gd+) brain lesions …

Autoimmune disease in first-degree relatives of patients with multiple sclerosis: a UK survey

SA Broadley, J Deans, SJ Sawcer, D Clayton… - Brain, 2000 - academic.oup.com
Previous studies examining an association with other autoimmune diseases have
suggested the existence of a generalized autoimmune diathesis in patients with multiple …

Role of the cervical lymphatics in the Th2-type hierarchy of CNS immune regulation

CJ Harling-Berg, JT Park, PM Knopf - Journal of neuroimmunology, 1999 - Elsevier
CNS immune regulation is intimately dependent on the dynamics of cerebral extracellular
fluid circulation. Animal models indicate that following the introduction of antigen into the …

Pregnancy and multiple sclerosis: an update on the disease modifying treatment strategy and a review of pregnancy's impact on disease activity

G Varytė, J Zakarevičienė, D Ramašauskaitė… - Medicina, 2020 - mdpi.com
Pregnancy rates are rapidly increasing among women of reproductive age diagnosed with
multiple sclerosis (MS). Through pre-conception, pregnancy and post-partum periods, there …

[HTML][HTML] Drug and neurofilament levels in serum and breastmilk of women with multiple sclerosis exposed to natalizumab during pregnancy and lactation

U Proschmann, R Haase, H Inojosa, K Akgün… - Frontiers in …, 2021 - frontiersin.org
Objective To determine the transfer of the monoclonal antibody natalizumab into breastmilk
and to evaluate drug and serum neurofilament light chain ((s) NfL) levels in natalizumab …

A history of previous childbirths is linked to women's white matter brain age in midlife and older age

I Voldsbekk, C Barth, II Maximov… - Human Brain …, 2021 - Wiley Online Library
Maternal brain adaptations occur in response to pregnancy, but little is known about how
parity impacts white matter and white matter ageing trajectories later in life. Utilising global …