Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

Proteins carry out a wide variety of catalytic, regulatory, signalling and structural functions in
living systems. Following their assembly on ribosomes and throughout their lifetimes, most …

Lysine L-lactylation [K (L-la)] is a newly discovered histone mark stimulated under conditions
of high glycolysis, such as the Warburg effect. K (L-la) is associated with functions that are …

Cysteine palmitoylation (S-palmitoylation) is a reversible post-translational modification that
is installed by the DHHC family of palmitoyltransferases and is reversed by several acyl …

Metabolism-mediated epigenetic changes represent an adapted mechanism for cellular
signaling, in which lysine acetylation and methylation have been the historical focus of …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet …

Protein S‐palmitoylation is a reversible post‐translational modification that alters the
localization, stability, and function of hundreds of proteins in the cell. S‐palmitoylation is …

Although there is little direct evidence supporting that stress affects cancer incidence, it does
influence the evolution, dissemination and therapeutic outcomes of neoplasia, as shown in …

Protein-based conjugates are valuable constructs for a variety of applications. Conjugation
of proteins to fluorophores is commonly used to study their cellular localization and the …