The causative agent of tuberculosis (TB), Mycobacterium tuberculosis and more recently
totally drug‐resistant strains of M. tuberculosis, display unique mechanisms to survive in the …

Tuberculosis (TB) remains one of the leading public health problems worldwide. Declared
as a global emergency in 1993 by the WHO, its control is hampered by the emergence of …

Infectious diseases caused by clinically important Mycobacteria continue to be an important
public health problem worldwide primarily due to emergence of drug resistance crisis. In …

Tuberculosis (TB) is the second most deadly infectious disease. Despite potentially curative
pharmacotherapies being available for over 50years, the length of the treatment and the pill …

Modern chemotherapy has significantly improved patient outcomes against drug-sensitive
tuberculosis. However, the rapid emergence of drug-resistant tuberculosis, together with the …

As a pharmacologically important heterocycle, oxadiazole paved the way to combat the
problem associated with the confluence of many commercially available drugs with different …

Palladium-catalyzed Suzuki–Miyaura cross-coupling of primary benzamides enabled by a
merger of site-selective N, N-di-Boc-activation and cooperative catalysis via N–C bond …

With nearly one-third of the global population infected by Mycobacterium tuberculosis, TB
remains a major cause of death (1.7 million in 2006). TB is particularly severe in parts of …

The increasing drug resistance of M ycobacterium tuberculosis to the currently used drugs
and HIV coinfection has caused alarm in the international scientific community …

The discovery of drugs is a lengthy, high-risk and expensive business taking at least 12
years and is estimated to cost upwards of US $800 million for each drug to be successfully …