An overview of new antitubercular drugs, drug candidates, and their targets
A Bahuguna, DS Rawat - Medicinal research reviews, 2020 - Wiley Online Library
The causative agent of tuberculosis (TB), Mycobacterium tuberculosis and more recently
totally drug‐resistant strains of M. tuberculosis, display unique mechanisms to survive in the …
totally drug‐resistant strains of M. tuberculosis, display unique mechanisms to survive in the …
Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs
PE Almeida Da Silva… - Journal of antimicrobial …, 2011 - academic.oup.com
Tuberculosis (TB) remains one of the leading public health problems worldwide. Declared
as a global emergency in 1993 by the WHO, its control is hampered by the emergence of …
as a global emergency in 1993 by the WHO, its control is hampered by the emergence of …
[HTML][HTML] New insights in to the intrinsic and acquired drug resistance mechanisms in mycobacteria
Infectious diseases caused by clinically important Mycobacteria continue to be an important
public health problem worldwide primarily due to emergence of drug resistance crisis. In …
public health problem worldwide primarily due to emergence of drug resistance crisis. In …
New old challenges in tuberculosis: potentially effective nanotechnologies in drug delivery
A Sosnik, ÁM Carcaboso, RJ Glisoni… - Advanced drug delivery …, 2010 - Elsevier
Tuberculosis (TB) is the second most deadly infectious disease. Despite potentially curative
pharmacotherapies being available for over 50years, the length of the treatment and the pill …
pharmacotherapies being available for over 50years, the length of the treatment and the pill …
Recent advancements in the development of anti-tuberculosis drugs
S Chetty, M Ramesh, A Singh-Pillay… - Bioorganic & medicinal …, 2017 - Elsevier
Modern chemotherapy has significantly improved patient outcomes against drug-sensitive
tuberculosis. However, the rapid emergence of drug-resistant tuberculosis, together with the …
tuberculosis. However, the rapid emergence of drug-resistant tuberculosis, together with the …
Oxadiazole: A highly versatile scaffold in drug discovery
N Desai, J Monapara, A Jethawa… - Archiv der …, 2022 - Wiley Online Library
As a pharmacologically important heterocycle, oxadiazole paved the way to combat the
problem associated with the confluence of many commercially available drugs with different …
problem associated with the confluence of many commercially available drugs with different …
Palladium-catalyzed Suzuki–Miyaura cross-coupling of amides via site-selective N–C bond cleavage by cooperative catalysis
G Meng, S Shi, M Szostak - Acs Catalysis, 2016 - ACS Publications
Palladium-catalyzed Suzuki–Miyaura cross-coupling of primary benzamides enabled by a
merger of site-selective N, N-di-Boc-activation and cooperative catalysis via N–C bond …
merger of site-selective N, N-di-Boc-activation and cooperative catalysis via N–C bond …
Rifamycins–obstacles and opportunities
PA Aristoff, GA Garcia, PD Kirchhoff, HDH Showalter - Tuberculosis, 2010 - Elsevier
With nearly one-third of the global population infected by Mycobacterium tuberculosis, TB
remains a major cause of death (1.7 million in 2006). TB is particularly severe in parts of …
remains a major cause of death (1.7 million in 2006). TB is particularly severe in parts of …
Antituberculosis drug research: a critical overview
Beena, DS Rawat - Medicinal research reviews, 2013 - Wiley Online Library
The increasing drug resistance of M ycobacterium tuberculosis to the currently used drugs
and HIV coinfection has caused alarm in the international scientific community …
and HIV coinfection has caused alarm in the international scientific community …
Target validation: linking target and chemical properties to desired product profile
PG Wyatt, IH Gilbert, KD Read… - Current topics in …, 2011 - ingentaconnect.com
The discovery of drugs is a lengthy, high-risk and expensive business taking at least 12
years and is estimated to cost upwards of US $800 million for each drug to be successfully …
years and is estimated to cost upwards of US $800 million for each drug to be successfully …