Recent advances in acid sensing by G protein coupled receptors

MD Glitsch - Pflügers Archiv-European Journal of Physiology, 2024 - Springer
Abstract Changes in extracellular proton concentrations occur in a variety of tissues over a
range of timescales under physiological conditions and also accompany virtually all …

Role of orphan G-protein coupled receptors in tissue ischemia: A comprehensive review

AK Bajestani, MS Alavi, L Etemad… - European Journal of …, 2024 - Elsevier
Ischemic events lead to many diseases and deaths worldwide. Ischemia/reperfusion (I/R)
occurs due to reduced blood circulation in tissues followed by blood reflow. Reoxygenation …

Targeting astrocytic TDAG8 with delayed CO2 postconditioning improves functional outcomes after controlled cortical impact injury in mice

SH Zhang, J Yin, LJ Jing, Y Cheng, YL Miao… - Experimental …, 2024 - Elsevier
T-cell death-associated gene 8 (TDAG8), a G-protein-coupled receptor sensing
physiological or weak acids, regulates inflammatory responses. However, its role in …

Targeting Neuronal GPR65 With Delayed BTB09089 Treatment Improves Neurorehabilitation Following Ischemic Stroke

R Chen, MQ Zhang, YL Miao, SH Zhang, Y Cheng… - Stroke, 2024 - ahajournals.org
BACKGROUND: GPR65 (G protein-coupled receptor 65) can sense extracellular acidic
environment to regulate pathophysiological processes. Pretreatment with the GPR65 …