In the 20 years since the first report of a proteolysis targeting chimeric (PROTAC) molecule,
targeted protein degradation (TPD) technologies have attempted to revolutionize the fields …

Targeted protein degradation (TPD) aids in developing novel bifunctional small-molecule
degraders and eliminates proteins of interest. The TPD approach shows promising results in …

The exquisite specificity of antibodies can be harnessed to effect targeted degradation of
membrane proteins. Here, we demonstrate targeted protein removal utilising a protein …

Cancer cells require high levels of iron for rapid proliferation, leading to a significant
upregulation of the iron carrier protein Transferrin Receptor (TfR) on their cell surface …

Targeted protein degradation (TPD) is a promising approach that has the ability to address
disease-causing proteins. Compared to traditional inhibition, proteolysis targeting chimera …

Hijacking the ubiquitin proteasome system to elicit targeted protein degradation (TPD) has
emerged as a promising therapeutic strategy to target and destroy intracellular proteins at …

Targeted protein degradation (TPD) strategy harnesses the ubiquitin-proteasome system
(UPS) to degrade a protein of interest (POI) by bringing it into proximity with an E3 ubiquitin …

Targeted protein degradation (TPD) is an emerging therapeutic approach that has attracted
significant interest. The traditional TPD degraders rely on small molecules that can only …

Chemically induced proximity (CIP) refers to co‐opting naturally occurring biological
pathways using synthetic molecules to recruit neosubstrates that are not normally …