Biological roles of adenine methylation in RNA

K Boulias, EL Greer - Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …

Hidden codes in mRNA: Control of gene expression by m6A

S Murakami, SR Jaffrey - Molecular cell, 2022 - cell.com
Information in mRNA has largely been thought to be confined to its nucleotide sequence.
However, the advent of mapping techniques to detect modified nucleotides has revealed …

N6-methyladenosine methyltransferases: functions, regulation, and clinical potential

W Huang, TQ Chen, K Fang, ZC Zeng, H Ye… - Journal of Hematology & …, 2021 - Springer
Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …

RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma

Y Cui, C Zhang, S Ma, Z Li, W Wang, Y Li, Y Ma… - Journal of Experimental …, 2021 - Springer
Background Long non-coding RNA (LncRNA) controls cell proliferation and plays a
significant role in the initiation and progression of esophageal squamous cell carcinoma …

RMBase v3. 0: decode the landscape, mechanisms and functions of RNA modifications

J Xuan, L Chen, Z Chen, J Pang, J Huang… - Nucleic Acids …, 2024 - academic.oup.com
Although over 170 chemical modifications have been identified, their prevalence,
mechanism and function remain largely unknown. To enable integrated analysis of diverse …

The multifaceted effects of YTHDC1-mediated nuclear m6A recognition

J Widagdo, V Anggono, JJL Wong - Trends in Genetics, 2022 - cell.com
N6-methyladenosine or m 6 A modification to mRNAs is now recognised as a key regulator
of gene expression and protein translation. The fate of m 6 A-modified mRNAs is decoded …

Emerging roles of RNA methylation in development

MK Wang, CC Gao, YG Yang - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus More than 170 different types of chemical modifications have been identified on
diverse types of RNA, collectively known as the epitranscriptome. Among them, N 6 …

Insight into the structure, physiological function, and role in cancer of m6A readers—YTH domain-containing proteins

J Liao, Y Wei, J Liang, J Wen, X Chen, B Zhang… - Cell death …, 2022 - nature.com
Abstract YT521-B homology (YTH) domain-containing proteins (YTHDF1-3, YTHDC1-2) are
the most crucial part of N6-methyladenosine (m6A) readers and play a regulatory role in …

[图书][B] RNA, the epicenter of genetic information

J Mattick, P Amaral - 2023 - library.oapen.org
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

LncSEA 2.0: an updated platform for long non-coding RNA related sets and enrichment analysis

G Zhang, C Song, S Fan, M Yin, X Wang… - Nucleic Acids …, 2024 - academic.oup.com
Long non-coding RNAs (lncRNAs) possess a wide range of biological functions, and
research has demonstrated their significance in regulating major biological processes such …