[HTML][HTML] Role of FGFR3 in bladder cancer: Treatment landscape and future challenges
CM Ascione, F Napolitano, D Esposito… - Cancer Treatment …, 2023 - Elsevier
Bladder cancer is a heterogeneous malignancy and is responsible for approximately 3.2%
of new diagnoses of cancer per year (Sung et al., 2021). Fibroblast Growth Factor Receptors …
of new diagnoses of cancer per year (Sung et al., 2021). Fibroblast Growth Factor Receptors …
Exploration of the antibody–drug conjugate clinical landscape
H Maecker, V Jonnalagadda, S Bhakta… - MAbs, 2023 - Taylor & Francis
The antibody–drug conjugate (ADC) field has undergone a renaissance, with substantial
recent developmental investment and subsequent drug approvals over the past 6 years. In …
recent developmental investment and subsequent drug approvals over the past 6 years. In …
FGFR-targeted therapeutics: Clinical activity, mechanisms of resistance and new directions
Fibroblast growth factor (FGF) signalling via FGF receptors (FGFR1–4) orchestrates fetal
development and contributes to tissue and whole-body homeostasis, but can also promote …
development and contributes to tissue and whole-body homeostasis, but can also promote …
Antibody-drug conjugates: Resurgent anticancer agents with multi-targeted therapeutic potential
C Ceci, PM Lacal, G Graziani - Pharmacology & Therapeutics, 2022 - Elsevier
Antibody–drug conjugates (ADCs) constitute a relatively new group of anticancer agents,
whose first appearance took place about two decades ago, but a renewed interest occurred …
whose first appearance took place about two decades ago, but a renewed interest occurred …
Antibody–Drug Conjugates for Multiple Myeloma: Just the Beginning, or the Beginning of the End?
U Ray, RZ Orlowski - Pharmaceuticals, 2023 - mdpi.com
Multiple myeloma is a malignancy of immunoglobulin-secreting plasma cells that is now
often treated in the newly diagnosed and relapsed and/or refractory settings with …
often treated in the newly diagnosed and relapsed and/or refractory settings with …
Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy
Emerging evidence indicates that cancer cells can mimic characteristics of embryonic
development, promoting their development and progression. Cancer cells share features …
development, promoting their development and progression. Cancer cells share features …
Clinical translation of antibody drug conjugate dosing in solid tumors from preclinical mouse data
B Rubahamya, S Dong, GM Thurber - Science Advances, 2024 - science.org
Antibody drug conjugates (ADCs) have made impressive strides in the clinic in recent years
with 11 Food and Drug Administration approvals, including 6 for the treatment of patients …
with 11 Food and Drug Administration approvals, including 6 for the treatment of patients …
[HTML][HTML] A novel strategy for treatment of bladder cancer: Antibody-drug conjugates
JH Kim, IH Chang - Investigative and clinical urology, 2022 - ncbi.nlm.nih.gov
In the past, there was no second-line chemotherapeutic agent suitable for use when
urothelial carcinoma (UC) progressed to platinum-resistant UC. However, recently, several …
urothelial carcinoma (UC) progressed to platinum-resistant UC. However, recently, several …
Molecular Targeting of the Fibroblast Growth Factor Receptor Pathway across Various Cancers
KS Shan, S Dalal, NN Thaw Dar, O McLish… - International Journal of …, 2024 - mdpi.com
Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases that are
involved in the regulation of cell proliferation, survival, and development. FGFR alterations …
involved in the regulation of cell proliferation, survival, and development. FGFR alterations …
FGFR alterations in head-and-neck cancer
Next‑generation sequencing The patient was initially unwilling for an NGS due to financial
constraints. However, as he was heavily pretreated and had exhausted almost all standard …
constraints. However, as he was heavily pretreated and had exhausted almost all standard …