[HTML][HTML] Role of FGFR3 in bladder cancer: Treatment landscape and future challenges

CM Ascione, F Napolitano, D Esposito… - Cancer Treatment …, 2023 - Elsevier
Bladder cancer is a heterogeneous malignancy and is responsible for approximately 3.2%
of new diagnoses of cancer per year (Sung et al., 2021). Fibroblast Growth Factor Receptors …

Exploration of the antibody–drug conjugate clinical landscape

H Maecker, V Jonnalagadda, S Bhakta… - MAbs, 2023 - Taylor & Francis
The antibody–drug conjugate (ADC) field has undergone a renaissance, with substantial
recent developmental investment and subsequent drug approvals over the past 6 years. In …

FGFR-targeted therapeutics: Clinical activity, mechanisms of resistance and new directions

M Katoh, Y Loriot, G Brandi, S Tavolari… - Nature Reviews …, 2024 - nature.com
Fibroblast growth factor (FGF) signalling via FGF receptors (FGFR1–4) orchestrates fetal
development and contributes to tissue and whole-body homeostasis, but can also promote …

Antibody-drug conjugates: Resurgent anticancer agents with multi-targeted therapeutic potential

C Ceci, PM Lacal, G Graziani - Pharmacology & Therapeutics, 2022 - Elsevier
Antibody–drug conjugates (ADCs) constitute a relatively new group of anticancer agents,
whose first appearance took place about two decades ago, but a renewed interest occurred …

Antibody–Drug Conjugates for Multiple Myeloma: Just the Beginning, or the Beginning of the End?

U Ray, RZ Orlowski - Pharmaceuticals, 2023 - mdpi.com
Multiple myeloma is a malignancy of immunoglobulin-secreting plasma cells that is now
often treated in the newly diagnosed and relapsed and/or refractory settings with …

Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy

J Cao, Z Zhang, L Zhou, M Luo, L Li, B Li, EC Nice… - MedComm, 2023 - Wiley Online Library
Emerging evidence indicates that cancer cells can mimic characteristics of embryonic
development, promoting their development and progression. Cancer cells share features …

Clinical translation of antibody drug conjugate dosing in solid tumors from preclinical mouse data

B Rubahamya, S Dong, GM Thurber - Science Advances, 2024 - science.org
Antibody drug conjugates (ADCs) have made impressive strides in the clinic in recent years
with 11 Food and Drug Administration approvals, including 6 for the treatment of patients …

[HTML][HTML] A novel strategy for treatment of bladder cancer: Antibody-drug conjugates

JH Kim, IH Chang - Investigative and clinical urology, 2022 - ncbi.nlm.nih.gov
In the past, there was no second-line chemotherapeutic agent suitable for use when
urothelial carcinoma (UC) progressed to platinum-resistant UC. However, recently, several …

Molecular Targeting of the Fibroblast Growth Factor Receptor Pathway across Various Cancers

KS Shan, S Dalal, NN Thaw Dar, O McLish… - International Journal of …, 2024 - mdpi.com
Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases that are
involved in the regulation of cell proliferation, survival, and development. FGFR alterations …

FGFR alterations in head-and-neck cancer

GS Panda, V Noronha, O Shetty, A Patil… - Cancer Research …, 2021 - journals.lww.com
Next‑generation sequencing The patient was initially unwilling for an NGS due to financial
constraints. However, as he was heavily pretreated and had exhausted almost all standard …