Stimuli-responsive ferroptosis for cancer therapy

N Kang, S Son, S Min, H Hong, C Kim, J An… - Chemical Society …, 2023 - pubs.rsc.org
Ferroptosis, an iron-dependent programmed cell death mechanism, is regulated by distinct
molecular pathways of lipid peroxidation caused by intracellular iron supplementation and …

Ferroptosis as a potential target for cancer therapy

Z Chen, W Wang, SR Abdul Razak, T Han… - Cell death & …, 2023 - nature.com
Ferroptosis is a recently discovered essential type of cell death that is mainly characterized
by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a …

[HTML][HTML] Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis

Q Lin, S Li, H Jin, H Cai, X Zhu, Y Yang… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Cisplatin is widely recommended in combination for the treatment of tumors, thus inevitably
increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of …

Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases

J Li, S Zheng, Y Fan, K Tan - Cell Death & Disease, 2023 - nature.com
Kidney diseases remain one of the leading causes of human death and have placed a
heavy burden on the medical system. Regulated cell death contributes to the pathology of a …

Ferroptosis: The entanglement between traditional drugs and nanodrugs in tumor therapy

K Liu, L Huang, S Qi, S Liu, W Xie, L Du… - Advanced …, 2023 - Wiley Online Library
Ferroptosis is a non‐apoptotic programmed cell death caused by the accumulation of lipid
peroxide. System Xc‐/glutathione peroxidase 4 (GPX4) axis and iron axis are two main …

The Chemical Reactivity of Membrane Lipids

G Duché, JM Sanderson - Chemical Reviews, 2024 - ACS Publications
It is well-known that aqueous dispersions of phospholipids spontaneously assemble into
bilayer structures. These structures have numerous applications across chemistry and …

Iron load toxicity in medicine: from molecular and cellular aspects to clinical implications

GJ Kontoghiorghes - International Journal of Molecular Sciences, 2023 - mdpi.com
Iron is essential for all organisms and cells. Diseases of iron imbalance affect billions of
patients, including those with iron overload and other forms of iron toxicity. Excess iron load …

Transformable Supramolecular Self‐Assembled Peptides for Cascade Self‐Enhanced Ferroptosis Primed Cancer Immunotherapy

H Wang, D Jiao, D Feng, Q Liu, Y Huang… - Advanced …, 2024 - Wiley Online Library
Immunotherapy has received widespread attention for its effective and long‐term tumor‐
eliminating ability. However, for immunogenic “cold” tumors, such as prostate cancer (PCa) …

Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction

L Jiaqi, H Siqing - Phytomedicine, 2023 - Elsevier
Background Ferroptosis, a form of regulated cell death by lipid peroxidation, was currently
considered as a key factor affecting the occurrence and progression in various cancers …

The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: glutamate accumulation

G Fan, M Liu, J Liu, Y Huang - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs
through over-stimulation of glutamate receptors, specifically NMDAR, while in the non …