The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …

Collectively referred to as the epitranscriptome, RNA modifications play important roles in
gene expression control regulating relevant cellular processes. In the last few decades …

Cajal bodies (CBs) are ubiquitous nuclear membraneless organelles (MLOs) that
concentrate and promote efficient biogenesis of snRNA-protein complexes involved in …

Small nucleolar (sno) RNAs guide posttranscriptional modifications essential for the
biogenesis and function of their target. The majority of snoRNAs in higher eukaryotes are …

Regulation of RNA helicase activity, often accomplished by protein cofactors, is essential to
ensure target specificity within the complex cellular environment. The largest family of RNA …

The nucleus of higher eukaryotes contains a number of structures that concentrate specific
biomolecules and play distinct roles in nuclear metabolism. In recent years, the molecular …

In eukaryotes, rRNAs and spliceosomal snRNAs are heavily modified post-transcriptionally.
Pseudouridylation and 2′-O-methylation are the most abundant types of RNA …

The nucleolus has long been perceived as the site for ribosome biogenesis, but numerous
studies suggest that the nucleolus carefully sequesters crucial proteins involved in multiple …

Functional genomics and systems biology have opened new doors to previously
inaccessible genomic information and holistic approaches to study complex networks of …

The formation of phase-separated condensates by many biomolecules is now widely
accepted as the basic principle of membrane-less organelle (MLO) formation in the cell …