[HTML][HTML] Recent advances in drug discovery for triple-negative breast cancer treatment
Triple-negative breast cancer (TNBC) is one of the most heterogeneous and aggressive
breast cancer subtypes with a high risk of death on recurrence. To date, TNBC is very …
breast cancer subtypes with a high risk of death on recurrence. To date, TNBC is very …
RNA-Binding Proteins in Breast Cancer: Biological Implications and Therapeutic Opportunities
S Wang, H Sun, G Chen, C Wu, B Sun, J Lin… - Critical Reviews in …, 2024 - Elsevier
RNA-binding proteins (RBPs) refer to a class of proteins that participate in alternative
splicing, RNA stability, polyadenylation, localization and translation of RNAs, thus regulating …
splicing, RNA stability, polyadenylation, localization and translation of RNAs, thus regulating …
Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions
I Malki, I Liepina, N Kogelnik, H Watmuff… - Nucleic Acids …, 2022 - academic.oup.com
Sam68, also known as KHDRBS1, is a member of the STAR family of proteins that directly
link signal transduction with post-transcriptional gene regulation. Sam68 controls the …
link signal transduction with post-transcriptional gene regulation. Sam68 controls the …
Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development
E Cesari, D Farini, V Medici, I Ehrmann… - Nucleic Acids …, 2024 - academic.oup.com
Sam68 and SLM2 are paralog RNA binding proteins (RBPs) expressed in the cerebral
cortex and display similar splicing activities. However, their relative functions during cortical …
cortex and display similar splicing activities. However, their relative functions during cortical …
Coalescent RNA-localizing and transcriptional activities of SAM68 modulate adhesion and subendothelial basement membrane assembly
Z Rekad, M Ruff, A Radwanska, D Grall, D Ciais… - Elife, 2023 - elifesciences.org
Endothelial cell interactions with their extracellular matrix are essential for vascular
homeostasis and expansion. Large-scale proteomic analyses aimed at identifying …
homeostasis and expansion. Large-scale proteomic analyses aimed at identifying …
[HTML][HTML] Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett's Esophagus
Simple Summary In the present study, we analyzed gene expression of NEK family
members (NEK1-NEK11) in esophageal adenocarcinoma (EAC) and its precancerous …
members (NEK1-NEK11) in esophageal adenocarcinoma (EAC) and its precancerous …
[HTML][HTML] Validating Sam68 expression and protein level in breast cancer
MK Khudhair, NI Mohammed… - Journal of Medicine and …, 2023 - ncbi.nlm.nih.gov
Breast carcinoma ranks as the second most common cancer among women worldwide.
Despite significant therapeutic advancements, approximately 25% of breast carcinoma …
Despite significant therapeutic advancements, approximately 25% of breast carcinoma …
[HTML][HTML] Screening of novel biomarkers for breast cancer based on WGCNA and multiple machine learning algorithms
X Jin, Z Huang, P Guo, R Yuan - Translational Cancer Research, 2023 - ncbi.nlm.nih.gov
Background Breast cancer (BC) ranks first in incidence among women, with approximately 2
million new cases per year. Therefore, it is essential to investigate emerging targets for BC …
million new cases per year. Therefore, it is essential to investigate emerging targets for BC …
Identifying and validating the prognosis and potential significance of Mitophagy related genes in breast cancer
H Zhao, Y Chen, Z Feng, Y Qin, Y Lin, J Luo, S Chen - 2024 - researchsquare.com
Background Breast cancer (BC) is a common malignant tumor with high incidence and
mortality rates. Mitophagy refers to a selective form of autophagy that is believed to be …
mortality rates. Mitophagy refers to a selective form of autophagy that is believed to be …