Nanodiamonds: the intersection of nanotechnology, drug development, and personalized medicine

D Ho, CHK Wang, EKH Chow - Science Advances, 2015 - science.org
The implementation of nanomedicine in cellular, preclinical, and clinical studies has led to
exciting advances ranging from fundamental to translational, particularly in the field of …

Nanotechnology based advanced therapeutic strategies for targeting interleukins in chronic respiratory diseases

MS Hussain, P Sharma, DS Dhanjal, N Khurana… - Chemico-biological …, 2021 - Elsevier
Both communicable and non-communicable chronic respiratory conditions have accorded
for suffering of millions of people of all ages and stated to be leading cause of death …

Tiotropium and olodaterol fixed-dose combination versus mono-components in COPD (GOLD 2–4)

R Buhl, F Maltais, R Abrahams… - European …, 2015 - Eur Respiratory Soc
Efficacy and safety of tiotropium+ olodaterol fixed-dose combination (FDC) compared with
the mono-components was evaluated in patients with moderate to very severe chronic …

Tiotropium versus salmeterol for the prevention of exacerbations of COPD

C Vogelmeier, B Hederer, T Glaab… - … England Journal of …, 2011 - Mass Medical Soc
Background Treatment guidelines recommend the use of inhaled long-acting
bronchodilators to alleviate symptoms and reduce the risk of exacerbations in patients with …

[HTML][HTML] Efficacy and safety of aclidinium bromide/formoterol fumarate fixed-dose combinations compared with individual components and placebo in patients with …

D Singh, PW Jones, ED Bateman, S Korn… - BMC pulmonary …, 2014 - Springer
Background Aclidinium/formoterol is a twice-daily (BID) fixed-dose combination (FDC) in
development for chronic obstructive pulmonary disease (COPD). The efficacy and safety of …

[HTML][HTML] Comparative efficacy of once-daily umeclidinium/vilanterol and tiotropium/olodaterol therapy in symptomatic chronic obstructive pulmonary disease: a …

GJ Feldman, AR Sousa, DA Lipson, L Tombs… - Advances in …, 2017 - Springer
Introduction We report the results of the first direct comparison of the once-daily fixed-dose
long-acting muscarinic antagonist/long-acting β 2-agonist (LAMA/LABA) combinations …

[HTML][HTML] Aclidinium bromide and formoterol fumarate as a fixed-dose combination in COPD: pooled analysis of symptoms and exacerbations from two six-month …

ED Bateman, KR Chapman, D Singh, AD D'Urzo… - Respiratory …, 2015 - Springer
Background The combination of aclidinium bromide, a long-acting anticholinergic, and
formoterol fumarate, a long-acting beta 2-agonist (400/12 μg twice daily) achieves …

[HTML][HTML] Efficacy and safety of glycopyrrolate/formoterol metered dose inhaler formulated using co-suspension delivery technology in patients with COPD

FJ Martinez, KF Rabe, GT Ferguson, LM Fabbri… - Chest, 2017 - Elsevier
Background Long-acting muscarinic antagonist (LAMA)/long-acting β 2-agonist (LABA)
combinations are a treatment option for patients with COPD who continue to have symptoms …

[HTML][HTML] The 24-h lung-function profile of once-daily tiotropium and olodaterol fixed-dose combination in chronic obstructive pulmonary disease

KM Beeh, J Westerman, AM Kirsten, J Hébert… - Pulmonary …, 2015 - Elsevier
Background This study investigated the effects on 24-h lung function and lung volume of a
once-daily fixed-dose combination (FDC) of the long-acting muscarinic antagonist tiotropium …

Lung function efficacy and symptomatic benefit of olodaterol once daily delivered via Respimat® versus placebo and formoterol twice daily in patients with GOLD 2–4 …

A Koch, E Pizzichini, A Hamilton, L Hart… - … journal of chronic …, 2014 - Taylor & Francis
Two replicate, multicenter, randomized, double-blind, placebo-controlled, parallel-group,
Phase III studies investigated the long-term efficacy and safety of once-daily olodaterol via …