In the past two decades, major breakthroughs that improve our understanding of the
pathophysiology and therapy of kidney stones (KS) have been lacking. The disease …

Oxalate homeostasis is maintained through a delicate balance between endogenous
sources, exogenous supply and excretion from the body. Novel studies have shed light on …

Background & Aims Cholemic nephropathy (CN) is a severe complication of cholestatic liver
diseases for which there is no specific treatment. We revisited its pathophysiology with the …

Kidney stone disease (KSD) is one of the earliest medical diseases known, but the
mechanism of its formation and metabolic changes remain unclear. The formation of kidney …

Hypoalbuminemia (HA) is frequently observed in systemic inflammatory diseases and in
liver disease. However, the influence of HA on the pharmacokinetics and toxicity of …

Nanomedicines are revolutionizing healthcare as recently demonstrated by the
Pfizer/BioNTech and Moderna COVID-2019 vaccines, with billions of doses administered …

Therapeutic approaches that lower circulating low-density lipoprotein (LDL)-cholesterol
significantly reduced the burden of cardiovascular disease over the last decades. However …

An in vitro/in silico method that determines the risk of human drug induced liver injury in
relation to oral doses and blood concentrations of drugs was recently introduced. This …

Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) is the most common
chronic liver disease in Western countries. It is becoming increasingly evident that …

Objective The incidence of metabolic dysfunction‐associated steatotic liver disease
(MASLD) is rapidly ramping up due to the spread of obesity, which is characterized by …