Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance
Fungal infections cause severe and life-threatening complications especially in
immunocompromised individuals. Antifungals targeting cellular machinery and cell …
immunocompromised individuals. Antifungals targeting cellular machinery and cell …
[HTML][HTML] Quinoline derivatives: promising antioxidants with neuroprotective potential
Quinoline has been proposed as a privileged molecular framework in medicinal chemistry.
Although by itself it has very few applications, its derivatives have diverse biological …
Although by itself it has very few applications, its derivatives have diverse biological …
[HTML][HTML] Photoluminescent lanthanide (III) coordination polymers with bis (1, 2, 4-triazol-1-yl) methane linker
EA Ivanova, KS Smirnova, IP Pozdnyakov, AS Potapov… - Inorganics, 2023 - mdpi.com
A series of new lanthanide (III) coordination polymers with the general formula [Ln (btrm) 2
(NO3) 3] n, where btrm= bis (1, 2, 4-triazol-1-yl) methane and Ln= Eu3+, Tb3+, Sm3+, Dy3+ …
(NO3) 3] n, where btrm= bis (1, 2, 4-triazol-1-yl) methane and Ln= Eu3+, Tb3+, Sm3+, Dy3+ …
The cytochrome P450 reductase CprA is a rate-limiting factor for Cyp51A-mediated azole resistance in Aspergillus fumigatus
A Kühbacher, P Merschak, H Haas… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Azole antifungals remain the “gold standard” therapy for invasive aspergillosis. The world-
wide emergence of isolates resistant to this drug class, however, developed into a steadily …
wide emergence of isolates resistant to this drug class, however, developed into a steadily …
Azole resistance in Aspergillus fumigatus- comprehensive review
M Dladla, M Gyzenhout, G Marias, S Ghosh - Archives of Microbiology, 2024 - Springer
Aspergillus fumigatus is a ubiquitous filamentous fungus commonly found in the
environment. It is also an opportunistic human pathogen known to cause a range of …
environment. It is also an opportunistic human pathogen known to cause a range of …
Isatin-semicarbazone linked acetamide 1, 2, 3-triazole hybrids: Synthesis, antimicrobial evaluation and docking simulations
N-Heterocycles stand out in medicinal chemistry as significant pharmacophores because of
their wide biological potential and structural diversity. In this perspective, we have …
their wide biological potential and structural diversity. In this perspective, we have …
From Synergy to Monotherapy: Discovery of Novel 2,4,6-Trisubstituted Triazine Hydrazone Derivatives with Potent Antifungal Potency In Vitro and In Vivo
F Xie, Y Hao, Y Liu, J Bao, R Wang, X Chi… - Journal of Medicinal …, 2024 - ACS Publications
Invasive fungal infections pose a serious threat to public health and are associated with high
mortality and incidence rates. The development of novel antifungal agents is urgently …
mortality and incidence rates. The development of novel antifungal agents is urgently …
[HTML][HTML] Transcriptomic meta-analysis to identify potential antifungal targets in Candida albicans
Background Candida albicans is a fungal pathogen causing human infections. Here we
investigated differential gene expression patterns and functional enrichment in C. albicans …
investigated differential gene expression patterns and functional enrichment in C. albicans …
5,6‐Dihydrotetrazolo[1,5‐c]quinazolines: Toxicity prediction, synthesis, antimicrobial activity, molecular docking, and perspectives
L Antypenko, O Antypenko, I Karnaukh… - Archiv der …, 2023 - Wiley Online Library
Antimicrobial resistance is a never‐ending challenge, which should be considered
seriously, especially when using unprescribed “over‐the‐counter” drugs. The synthesis and …
seriously, especially when using unprescribed “over‐the‐counter” drugs. The synthesis and …
Anti-Infection of Oral Microorganisms from Herbal Medicine of Piper crocatum Ruiz & Pav
Abstract The WHO Global Status Report on Oral Health 2022 reveals that oral diseases
caused by infection with oral pathogenic microorganisms affect nearly 3.5 billion people …
caused by infection with oral pathogenic microorganisms affect nearly 3.5 billion people …