[HTML][HTML] IDO/kynurenine pathway in cancer: possible therapeutic approaches

EE Abd El-Fattah - Journal of Translational Medicine, 2022 - Springer
Cancer is one of the leading causes of death in both men and women worldwide. One of the
main changes associated with cancer progression, metastasis, recurrence, and …

Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis

EE Abd EL-Fattah, R Michel, MA Borahay - Cytokine & Growth Factor …, 2023 - Elsevier
Uterine fibroids (UF), also called uterine leiomyoma, is one of the most prevalent uterine
tumors. UF represents a serious women's health global problem with a significant physical …

[HTML][HTML] Metformin and its immune-mediated effects in various diseases

I Nojima, J Wada - International journal of molecular sciences, 2023 - mdpi.com
Metformin has been a long-standing prescribed drug for treatment of type 2 diabetes (T2D)
and its beneficial effects on virus infection, autoimmune diseases, aging and cancers are …

Endoplasmic reticulum stress and metabolism in hepatocellular carcinoma

C Luna-Marco, A Ubink, M Kopsida… - The American Journal of …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer,
accounting for 85% to 90% of all liver cancer cases. It is a hepatocyte-derived primary tumor …

[HTML][HTML] Tumor necrosis factor-alpha and adiponectin in nonalcoholic fatty liver disease-associated hepatocellular carcinoma

ID Vachliotis, I Valsamidis, SA Polyzos - Cancers, 2023 - mdpi.com
Simple Summary The prevalence of nonalcoholic fatty liver disease (NAFLD)-associated
hepatocellular carcinoma (HCC) is rapidly increasing, following the growing prevalence of …

Reprograming immune microenvironment modulates CD47 cancer stem cells in hepatocellular carcinoma

EE Abd El-Fattah, HM Selim - International Immunopharmacology, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. There are different
therapeutic approaches to cancer eradication such as chemotherapy, radiotherapy, and …

Metformin: a promising antidiabetic medication for cancer treatment

W Mu, Y Jiang, G Liang, Y Feng, F Qu - Current Drug Targets, 2023 - ingentaconnect.com
Metformin is a widely used drug in patients with type 2 diabetes mellitus. Metformin inhibits
hepatic gluconeogenesis and increases glucose utilization in peripheral tissues. In recent …

[HTML][HTML] Targeting HSP47 and HSP70: promising therapeutic approaches in liver fibrosis management

EE Abd El-Fattah, AY Zakaria - Journal of Translational Medicine, 2022 - Springer
Liver fibrosis is a liver disease in which there is an excessive buildup of extracellular matrix
proteins, including collagen. By regulating cytokine production and the inflammatory …

[HTML][HTML] Repurposing drugs for solid tumor treatment: focus on immune checkpoint inhibitors

Q Liu, L Li, W Qin, T Chao - Cancer Biology & Medicine, 2023 - ncbi.nlm.nih.gov
Cancer remains a significant global health challenge with limited treatment options beyond
systemic therapies, such as chemotherapy, radiotherapy, and molecular targeted therapy …

Tumor lysis syndrome promotes cancer chemoresistance and relapse through AMPK inhibition

EE Abd El-Fattah - International Immunopharmacology, 2023 - Elsevier
Cancer is a disease caused when cells divide uncontrollably and spread into surrounding
tissues. There are different therapeutic modalities that control cancer growth, of which …