Aging is the leading risk factor for several age-associated diseases such as
neurodegenerative diseases. Understanding the biology of aging mechanisms is essential …

In this monograph, we ask whether various kinds of intellectual, physical, and social
activities produce cognitive enrichment effects—that is, whether they improve cognitive …

A potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons was
purified and cloned. Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated …

Brain‐derived neurotrophic factor (BDNF) is a neurotrophin, which plays an important role in
the central nervous system, and systemic or peripheral inflammatory conditions, such as …

CREB is a transcription factor implicated in the control of adaptive neuronal responses.
Although one function of CREB in neurons is believed to be the regulation of genes whose …

In recent years, nerve growth factor (NGF) has gained attention as a potential therapeutic
agent for Alzheimer's disease (AD). To study the expression of NGF and its homologs, brain …

Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to
nerve growth factor, which is abundantly and widely expressed in the adult mammalian …

We provide a brief review of the literature on exercise effects on brain and cognition. To this
end, we focus on both prospective and retrospective human epidemiological studies that …

Brain-derived neurotrophic factor (BDNF) supports the survival of a specific set of neurons in
the vertebrate nervous system. Here we show that the rat BDNF gene consists of four short …

Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
mammalian brain, essential not only to the development of the central nervous system but …