Organ transplantation is undergoing profound changes. Contraindications for donation have
been revised in order to better meet the organ demand. The use of lower-quality organs and …

Kidney transplantation remains the gold standard treatment for patients suffering from end-
stage kidney disease. To meet the constantly growing organ demands grafts donated after …

Prompted by the utilization of extended criteria donors, dual hypothermic oxygenated
machine perfusion (D-HOPE) was introduced in liver transplantation to improve …

Because of the high demand of organs, the usage of marginal grafts has increased. These
marginal organs have a higher risk of developing ischemia-reperfusion injury, which can …

Normothermic machine perfusion (NMP) technologies are emerging as an important adjunct
in organ preservation and transplantation. NMP can enable the reduction or avoidance of …

The increased utilization of high-risk renal grafts for transplantation requires optimization of
pretransplant organ assessment strategies. Current decision-making methods to accept an …

Mitochondria sense changes resulting from the ischemia and subsequent reperfusion of an
organ and mitochondrial reactive oxygen species (ROS) production initiates a series of …

Abstract Purpose of Review Human pancreas-on-a-chip (PoC) technology is quickly
advancing as a platform for complex in vitro modeling of islet physiology. This review …

The increasing use of donation after circulatory death (DCD) and extended criteria donor
(ECD) organs has raised awareness of the need to improve the quality of kidneys for …

Although solid organ transplantation remains the definitive management for patients with
end-stage organ failure, this ultimate treatment has been limited by the number of …