Metabolic and toxic liver disorders, such as fatty liver disease (steatosis) and drug-induced
liver injury, are highly prevalent and potentially life-threatening. To allow for the study of …

Solid organ transplantation provides a definitive treatment for end-stage organ failure. The
clinical field has progressed rapidly since its early beginnings during the latter half of the …

Grafts from donors after cardiac death (DCD) have greatly contributed to expanding the
donor organ pool. This study aimed to determine the benefits of subnormothermic …

Transplantation represents the treatment of choice for many end-stage diseases but is
limited by the shortage of healthy donor organs. Ex situ normothermic machine perfusion …

Background: In contrast to traditional static cold preservation of donor livers, normothermic
machine perfusion (NMP) may reduce preservation injury, improve graft viability and …

Hypothermic machine perfusion (HMP) is a method that can be more effective in preserving
donor organs compared with cold storage (CS). However, the optimal duration and the exact …

Organ transplantation remains the only treatment option for patients with end-stage organ
failure. The last decade has seen a flurry of activity in improving organ preservation …

Background. Pancreas and islet transplantation outcomes are negatively impacted by injury
to the endocrine cells from acute stress during donor death, organ procurement, processing …

Background In contemporary transplantation research, the utilization of machine perfusion to
facilitate the perfusion, preservation, evaluation, and repair of donor livers has garnered …

Kidney transplantation is at present the only definitive treatment for patients with end-stage
kidney disease that can improve the quality of life compared with dialysis. However, donor …