[HTML][HTML] Stem cell-based therapy for human diseases

DM Hoang, PT Pham, TQ Bach, ATL Ngo… - Signal transduction and …, 2022 - nature.com
Recent advancements in stem cell technology open a new door for patients suffering from
diseases and disorders that have yet to be treated. Stem cell-based therapy, including …

[HTML][HTML] Role of Microglia and Astrocytes in Alzheimer's Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

G Di Benedetto, C Burgaletto, CM Bellanca, A Munafò… - Cells, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia worldwide, with a complex,
poorly understood pathogenesis. Cerebral atrophy, amyloid-β (Aβ) plaques, and …

[HTML][HTML] MG53 protein rejuvenates hUC-MSCs and facilitates their therapeutic effects in AD mice by activating Nrf2 signaling pathway

S Ma, X Zhou, Y Wang, Z Li, Y Wang, J Shi, F Guan - Redox Biology, 2022 - Elsevier
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) transplantation is a
promising therapy for Alzheimer's disease (AD). However, hUC-MSCs cultured in vitro easily …

[HTML][HTML] Emerging polymeric biomaterials and manufacturing-based tissue engineering approaches for neuro regeneration-A critical review on recent effective …

A Akhtar, VF Rad, AR Moradi, M Yar… - Smart Materials in …, 2023 - Elsevier
The nervous system is a crucial part of the human body that is damaged by traumatic injury,
stroke, and neurodegenerative diseases. Recent studies also have shown that …

[HTML][HTML] Advances in nanotechnology versus stem cell therapy for the theranostics of Huntington's disease

G Mustafa, D Hassan, M Zeeshan, G Ruiz-Pulido… - Journal of Drug Delivery …, 2023 - Elsevier
Huntington's disease (HD) is a neurological disorder characterized by a reduction in
medium-spiny neurons in the brain. Currently, there is no cure for HD and treatment relies …

KLF2 regulates neural differentiation of dental pulp-derived stem cells by modulating autophagy and mitophagy

P Prateeksha, P Naidu, M Das, D Barthels… - Stem Cell Reviews and …, 2023 - Springer
Background Transplantation of stem cells for treating neurodegenerative disorders is a
promising future therapeutic approach. However, the molecular mechanism underlying the …

[HTML][HTML] Stem cell therapy for central nervous system disorders: Metabolic interactions between transplanted cells and local microenvironments

SA Sakowski, KS Chen - Neurobiology of disease, 2022 - Elsevier
Stem cell therapy is a promising and rapidly advancing treatment strategy for a multitude of
neurologic disorders. Yet, while early phase clinical trials are being pursued in many …

Cellular therapeutic potential of genetically engineered stem cells in cancer treatment

EK Sher, A Kalić, A Džidić-Krivić, MB Zećo… - Biotechnology and …, 2023 - Taylor & Francis
Traditional therapeutic approaches in the treatment of cancer have many side effects and
are often ineffective and non-specific, leading to the development of therapy-resistant …

Adipose tissue‐derived mesenchymal stem cells ameliorate cognitive impairment in Alzheimer's disease rat model: Emerging role of SIRT1

M Nabil, DH Kassem, AA Ali, HO El‐Mesallamy - BioFactors, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a complex form of neurodegenerative dementia. Growing body
of evidence supports the cardinal role of sirtuin1 (SIRT1) in neurodegeneration and AD …

[HTML][HTML] Generation of the first human in vitro model for McArdle disease based on iPSC technology

MC Ortuño-Costela, V Cerrada… - International Journal of …, 2022 - mdpi.com
McArdle disease is a rare autosomal recessive disorder caused by mutations in the PYGM
gene. This gene encodes for the skeletal muscle isoform of glycogen phosphorylase …