Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics

R Tenchov, JM Sasso, X Wang, WS Liaw, CA Chen… - ACS …, 2022 - ACS Publications
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

[HTML][HTML] A review on exosomes application in clinical trials: perspective, questions, and challenges

J Rezaie, M Feghhi, T Etemadi - Cell Communication and Signaling, 2022 - Springer
Background Exosomes are progressively known as significant mediators of cell-to-cell
communication. They convey active biomolecules to target cells and have vital functions in …

[HTML][HTML] Review on strategies and technologies for exosome isolation and purification

J Chen, P Li, T Zhang, Z Xu, X Huang… - … in bioengineering and …, 2022 - frontiersin.org
Exosomes, a nano-sized subtype of extracellular vesicles secreted from almost all living
cells, are capable of transferring cell-specific constituents of the source cell to the recipient …

[HTML][HTML] Exosomes and ectosomes in intercellular communication

J Meldolesi - Current Biology, 2018 - cell.com
Exosomes and ectosomes, two distinct types of extracellular vesicles generated by all types
of cell, play key roles in intercellular communication. The formation of these vesicles …

[HTML][HTML] Lysosomal exocytosis, exosome release and secretory autophagy: the autophagic-and endo-lysosomal systems go extracellular

S Buratta, B Tancini, K Sagini, F Delo… - International journal of …, 2020 - mdpi.com
Beyond the consolidated role in degrading and recycling cellular waste, the autophagic-and
endo-lysosomal systems play a crucial role in extracellular release pathways. Lysosomal …

[HTML][HTML] Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

M Sardar Sinha, A Ansell-Schultz, L Civitelli… - Acta …, 2018 - Springer
The gradual deterioration of cognitive functions in Alzheimer's disease is paralleled by a
hierarchical progression of amyloid-beta and tau brain pathology. Recent findings indicate …

[HTML][HTML] Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

D Ha, N Yang, V Nadithe - Acta Pharmaceutica Sinica B, 2016 - Elsevier
Exosomes are small intracellular membrane-based vesicles with different compositions that
are involved in several biological and pathological processes. The exploitation of exosomes …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications

S Rani, AE Ryan, MD Griffin, T Ritter - Molecular Therapy, 2015 - cell.com
Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate
into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the …

[HTML][HTML] Progress of exosomes in the diagnosis and treatment of lung cancer

K Xu, C Zhang, T Du, ANA Gabriel, X Wang, X Li… - Biomedicine & …, 2021 - Elsevier
The incidence and mortality of lung cancer account for first place all over the world. Lung
cancer lacks early diagnostic biomarkers; lung cancer patients are usually diagnosed in …

Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy

J Phan, P Kumar, D Hao, K Gao… - Journal of extracellular …, 2018 - Taylor & Francis
Through traditional medicine, there were diseases and disorders that previously remained
untreated or were simply thought to be incurable. Since the discovery of mesenchymal stem …