Purpose While corticosteroids are relatively inexpensive and commonly used as treatment
for a variety of conditions, long-term use is known to be associated with certain toxicities …

Glucocorticoids remain widely used for many medical conditions, and fractures are the most
serious common adverse event related to long-term glucocorticoid use. Glucocorticoid …

Glucocorticoids are effective immunomodulatory drugs used for many inflammatory
disorders as well as in transplant recipients. However, both iatrogenic and endogenous …

This paper provides a framework for the development of national guidelines for the
management of glucocorticoid-induced osteoporosis in men and women aged 18 years and …

Introduction: Glucocorticoid-induced osteoporosis (GIOP) is one of the most devastating side-
effects of glucocorticoid (GC) use, as it is associated with an increased fracture risk. The …

Harvey Cushing first described the association between excess endogenous glucocorticoids
and fractures in 1932. 1 Within a few years after the introduction of prednisone to treat …

This study aims to estimate bisphosphonate effectiveness by comparing fracture incidence
over time on therapy in glucocorticoid-induced osteoporosis (GIO). From this observational …

More than 70 years ago, osteoporosis associated with endogenous glucocorticoid excess
was described by Harvey Cushing. More common is the increased fracture risk associated …

Background Genetic factors are important in the pathogenesis of osteoporosis, but less is
known about the genetic determinants of osteoporosis treatment. We aimed to explore the …

Background and objective Markov micro-simulation models are being increasingly used in
health economic evaluations. An important feature of the Markov micro-simulation model is …