Increased oxidative stress has been associated with the aging process. However, recent
studies have revealed that a low-level oxidative stress can even extend the lifespan of …

ABSTRACT A common, long‐held belief is that metabolic rate drives the rates of various
biological, ecological and evolutionary processes. Although this metabolic pacemaker view …

Summary The mammalian Sir2 ortholog Sirt1 plays an important role in metabolic
regulation. However, the role of Sirt1 in the regulation of aging and longevity is still …

Liver zonation, the spatial separation of the immense spectrum of different metabolic
pathways along the liver sinusoids, is fundamental for proper functioning of this organ …

Growth hormone (GH) and insulin-like growth factor-1 (IGF-I) are pleiotropic hormones with
important roles in lifespan. They promote growth, anabolic actions, and body maintenance …

The mouse has rapidly become the mammalian model organism of choice in ageing
research due to its relatively short lifespan, the proximity of its genome and physiology to …

Coordinated expression of mitochondrial and nuclear genes is required to maintain proper
mitochondrial function. However, the precise mechanisms that ensure this coordination are …

Studies in humans and in animal models show negative correlations between thyroid
hormone (TH) levels and longevity. TH signaling is implicated in maintaining and integrating …

Xenobiotic metabolism has been proposed to play a role in modulating the rate of aging.
Xenobiotic metabolizing enzymes (XME) are expressed at higher levels in calorically …

Cellular senescence has gained much attention as a contributor to aging and susceptibility
to disease. Senescent cells undergo a stable cell cycle arrest and produce pro-inflammatory …