Epilepsy is one of the most common and disabling neurologic conditions, yet we have an
incomplete understanding of the detailed pathophysiology and, thus, treatment rationale for …

Epilepsy is characterized by recurrent spontaneous seizures due to hyperexcitability and
hypersynchrony of brain neurons. Current theories of pathophysiology stress neuronal …

Antiseizure drugs (ASDs), also termed antiepileptic drugs, are the main form of symptomatic
treatment for people with epilepsy, but not all patients become free of seizures. The …

The current spectrum of disorders associated to clinical spasms with onset in infancy is
wider than previously thought; accordingly, its terminology has changed. Nowadays, the …

Children with infantile spasms are likely to have a poor outcome. Outcome measures for
infantile spasms include primary response to treatment, relapse of spasms, neurological …

Relapses are a hallmark of multiple sclerosis (MS), and are often associated with significant
functional impairment and decreased quality of life; we review the pathophysiology of MS …

Background Tuberous sclerosis complex is a multiorgan disease resulting from a mutation of
one of two TSC genes. The two gene products form a functional complex that regulates the …

West syndrome (WS), also known as infantile spasms, occurs in infancy with a peak
between 4 and 7 months. Spasms, neurodevelopmental regression and hypsarrhythmia on …

Although anti-inflammatory drugs are among the most common class of marketed drugs,
chronic inflammatory conditions such as rheumatoid arthritis, multiple sclerosis or …

Identifying effective therapies for the treatment of progressive forms of multiple sclerosis
(MS) is a highly relevant priority and one of the greatest challenges for the global MS …