Evolving therapeutic landscape of advanced hepatocellular carcinoma

C Yang, H Zhang, L Zhang, AX Zhu… - Nature reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …

Molecular signaling pathways and therapeutic targets in hepatocellular carcinoma

M Dimri, A Satyanarayana - Cancers, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is a complex biological process and is often diagnosed at
advanced stages with no effective treatment options. With advances in tumor biology and …

Pathogenesis and current treatment strategies of hepatocellular carcinoma

D Tümen, P Heumann, K Gülow, CN Demirci… - Biomedicines, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is the most frequent liver cancer with high lethality and low
five-year survival rates leading to a substantial worldwide burden for healthcare systems …

miRNAs inspirations in hepatocellular carcinoma: detrimental and favorable aspects of key performers

HA El-Mahdy, AAM Sallam, A Ismail… - … -Research and practice, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths
worldwide. HCC initiation, progression, and therapy failure are all influenced by various …

Role of nonresolving inflammation in hepatocellular carcinoma development and progression

LX Yu, Y Ling, HY Wang - NPJ precision oncology, 2018 - nature.com
Hepatocellular carcinoma (HCC) has become a leading cause of cancer-related death,
making the elucidation of its underlying mechanisms an urgent priority. Inflammation is an …

PI3K/Akt/mTOR pathway as a therapeutic target for colorectal cancer: a review of preclinical and clinical evidence

A Narayanankutty - Current drug targets, 2019 - ingentaconnect.com
Background: Phosphoinositide 3-kinase (PI3Ks) is a member of intracellular lipid kinases
and involved in the regulation of cellular proliferation, differentiation and survival …

Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers

Y Wang, B Deng - Cancer and Metastasis Reviews, 2023 - Springer
Hepatocellular carcinoma (HCC) is a common malignancy and one of the leading causes of
cancer-related death. The biological process of HCC is complex, with multiple factors …

CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β …

XL Ma, MN Shen, B Hu, BL Wang, WJ Yang… - Journal of hematology & …, 2019 - Springer
Background Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies
worldwide because of rapid progression and high incidence of metastasis or recurrence …

[HTML][HTML] Hydrodynamic transfection for generation of novel mouse models for liver cancer research

X Chen, DF Calvisi - The American journal of pathology, 2014 - Elsevier
Primary liver cancers, including hepatocellular carcinoma and intrahepatic
cholangiocarcinoma, are leading causes of cancer-related death worldwide. Recent large …

Targeting the Ras/Raf/MEK/ERK pathway in hepatocellular carcinoma

S Yang, G Liu - Oncology letters, 2017 - spandidos-publications.com
Although the biological basis of hepatocellular carcinoma (HCC) remains unclear, effective
treatments and improvement of the survival rate remain worthwhile research goals …