The pathophysiology of gestational diabetes mellitus

JF Plows, JL Stanley, PN Baker, CM Reynolds… - International journal of …, 2018 - mdpi.com
Gestational diabetes mellitus (GDM) is a serious pregnancy complication, in which women
without previously diagnosed diabetes develop chronic hyperglycemia during gestation. In …

Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child

PM Catalano, K Shankar - Bmj, 2017 - bmj.com
Obesity is the most common medical condition in women of reproductive age. Obesity during
pregnancy has short term and long term adverse consequences for both mother and child …

Maternal–fetal nutrient transport in pregnancy pathologies: the role of the placenta

KE Brett, ZM Ferraro, J Yockell-Lelievre… - International journal of …, 2014 - mdpi.com
Appropriate in utero growth is essential for offspring development and is a critical contributor
to long-term health. Fetal growth is largely dictated by the availability of nutrients in maternal …

Trying to understand gestational diabetes

PM Catalano - Diabetic Medicine, 2014 - Wiley Online Library
Women with normal glucose tolerance pre‐gravid and developing gestational diabetes in
late gestation have subclinical metabolic dysfunction prior to conception compared with …

Maternal obesity and fetal metabolic programming: a fertile epigenetic soil

MJR Heerwagen, MR Miller… - American Journal of …, 2010 - journals.physiology.org
The incidence of obesity and overweight has reached epidemic levels in the United States
and developed countries worldwide. Even more alarming is the increasing prevalence of …

[HTML][HTML] Obesity, insulin resistance and pregnancy outcome

PM Catalano - Reproduction (Cambridge, England), 2010 - ncbi.nlm.nih.gov
There has been a significant increase over the past few decades in the number of
reproductive age women who are either overweight or obese. Overweight and obese …

Elimination of “kitome” and “splashome” contamination results in lack of detection of a unique placental microbiome

IN Olomu, LC Pena-Cortes, RA Long, A Vyas… - BMC microbiology, 2020 - Springer
Background A placental microbiome, which may be altered in gestational diabetes mellitus
(GDM), has been described. However, publications raising doubts about the existence of a …

[HTML][HTML] Perinatal risk factors for childhood obesity and metabolic dysregulation

PM Catalano, K Farrell, A Thomas… - The American journal of …, 2009 - Elsevier
Background Childhood obesity has increased significantly in recent decades. Objective The
objective was to examine the perinatal risk factors related to childhood obesity. Design In a …

Developmental origins of NAFLD: a womb with a clue

SR Wesolowski, KCE Kasmi, KR Jonscher… - Nature reviews …, 2017 - nature.com
Abstract Changes in the maternal environment leading to an altered intrauterine milieu can
result in subtle insults to the fetus, promoting increased lifetime disease risk and/or disease …

Is it time to revisit the Pedersen hypothesis in the face of the obesity epidemic?

PM Catalano, S Hauguel-De Mouzon - American journal of obstetrics and …, 2011 - Elsevier
The Pedersen hypothesis was formulated more than 50 years ago. Jorgen Pedersen
primarily cared for women with type 1 diabetes. He suggested that fetal overgrowth was …