A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …

Mechanobiology is a domain of interdisciplinary research that aims to explore the impact of
physical force, applied externally or internally, on cell and tissue function, including …

It is recognized that the changes in the physical properties of extracellular matrix (ECM)
result in fine‐tuned cell responses including cell morphology, proliferation and …

Liver resection causes marked perfusion alterations in the liver remnant both on the organ
scale (vascular anatomy) and on the microscale (sinusoidal blood flow on tissue level) …

Hepatic fibrosis is the common pathway for most chronic liver diseases, characterized by
excessive accumulation of extracellular matrix (ECM) proteins. It has been shown that …

Bioprinting is a key technique to fabricate cell-laden volumetric constructs with controlled
geometry. It can be used not only to replicate the architecture of a target organ but also to …

Liver tissue engineering approaches aim to support drug testing, assistance devices, or
transplantation. However, their suitability for clinical application remains unsatisfactory …

Advances in microsystem engineering have enabled the development of highly controlled
models of the liver that better recapitulate the unique in vivo biological conditions. In just a …

The extracellular matrix (ECM) provides physical support and imparts significant
biochemical and mechanical cues to cells. Matrix stiffening is a hallmark of liver fibrosis and …

Chronic liver disease or repeated damage to hepatocytes can give rise to hepatic fibrosis.
Hepatic fibrosis is a pathological process of excessive sedimentation of extracellular matrix …