Background: When healthcare professionals or other involved parties prevent eligible
patients from entering a trial as a research subject, they are gatekeeping. This phenomenon …

Adolescents and young adults (AYAs) with cancer are a heterogeneous group.
Nevertheless, there are sufficient unifying characteristics to form a distinct clinical entity …

Objective To develop a novel prognostic indicator for use in patients with advanced cancer
that is significantly better than clinicians' estimates of survival. Design Prospective …

Purpose: Palliative care is increasingly viewed as a necessary component of cancer care,
especially for patients with advanced disease. Rigorous clinical trials are thus needed to …

There has been a paradigm shift in medicine away from tradition, anecdote and theoretical
reasoning from the basic sciences towards evidence-based medicine (EBM). In palliative …

Background: Barriers to randomised clinical trial (RCT) recruitment include failure to identify
eligible patients, reluctance of staff to approach them and attitudes of some health-care …

To successfully implement a pragmatic clinical trial, investigators need access to numerous
resources, including financial support, institutional infrastructure (eg clinics, facilities, staff) …

This second article in the series on pragmatic trials describes the challenges in selection of
sites for pragmatic clinical trials and the impact on validity, precision, and generalizability of …

The concept of clinical trial feasibility is of great interest to the community of palliative care
researchers, clinicians, and granting agencies. Significant allocation of resources is required …

Background: Recruitment to paediatric palliative care research is challenging, with high
rates of non-invitation of eligible families by clinicians. The impact on sample characteristics …