[HTML][HTML] Mitochondrial electron transport chain, ROS generation and uncoupling

RZ Zhao, S Jiang, L Zhang… - … journal of molecular …, 2019 - spandidos-publications.com
The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as
well as the electron transporters ubiquinone and cytochrome c. There are two electron …

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

MD Brand - Free Radical Biology and Medicine, 2016 - Elsevier
This review examines the generation of reactive oxygen species by mammalian
mitochondria, and the status of different sites of production in redox signaling and pathology …

[HTML][HTML] SARS-CoV-2 mediated endothelial dysfunction: the potential role of chronic oxidative stress

R Chang, A Mamun, A Dominic, NT Le - Frontiers in physiology, 2021 - frontiersin.org
Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19
inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation …

Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity

HE Kunz, CR Hart, KJ Gries, M Parvizi… - American Journal …, 2021 - journals.physiology.org
Obesity is accompanied by numerous systemic and tissue-specific derangements, including
systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal …

[HTML][HTML] Bacterial pigments: sustainable compounds with market potential for pharma and food industry

CK Venil, L Dufossé, P Renuka Devi - Frontiers in Sustainable Food …, 2020 - frontiersin.org
The continued universal application of synthetic colorants for decades have caused
environmental pollutions and human health vulnerabilities. So, it was indispensable to …

[HTML][HTML] Mitochondrial dysfunction: the hidden player in the pathogenesis of atherosclerosis?

G Ciccarelli, S Conte, G Cimmino, P Maiorano… - International Journal of …, 2023 - mdpi.com
Atherosclerosis is a multifactorial inflammatory pathology that involves metabolic processes.
Improvements in therapy have drastically reduced the prognosis of cardiovascular disease …

AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of …

B Szczesny, K Módis, K Yanagi, C Coletta… - Nitric oxide, 2014 - Elsevier
The purpose of the current study was to investigate the effect of the recently synthesized
mitochondrially-targeted H 2 S donor, AP39 [(10-oxo-10-(4-(3-thioxo-3H-1, 2-dithiol-5yl) …

Inflammation and atherosclerosis—revisited

S Pant, A Deshmukh, GS GuruMurthy… - Journal of …, 2014 - journals.sagepub.com
Atherogenesis has been traditionally viewed as a metabolic disease representing arterial
obstruction by fatty deposits in its wall. Today, it is believed that atherogenesis involves …

Riding the tiger–physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix

MD Brand - Critical Reviews in Biochemistry and Molecular Biology, 2020 - Taylor & Francis
Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

[HTML][HTML] Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties

JC Lee, MF Hou, HW Huang, FR Chang, CC Yeh… - Cancer cell …, 2013 - Springer
For their various bioactivities, biomaterials derived from marine algae are important
ingredients in many products, such as cosmetics and drugs for treating cancer and other …