It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …

Lottery, luck, or legacy. A review of “The Genetic Lottery: Why DNA matters for social equality” -
PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …

A central aim of genome-wide association studies (GWASs) is to estimate direct genetic
effects: the causal effects on an individual's phenotype of the alleles that they carry …

The genotyping of millions of human samples has made it possible to evaluate variants
across the human genome for their possible association with risks for numerous diseases …

Principal component analysis (PCA) and F-statistics sensu Patterson are two of the most
widely used population genetic tools to study human genetic variation. Here, I derive explicit …

Lewontin's 1972 article 'The apportionment of human diversity'described a key feature of
human genetic diversity that would have profound impacts on conversations regarding …

Populations can adapt to novel selection pressures through dramatic frequency changes in
a few genes of large effect or subtle shifts in many genes of small effect. The latter (polygenic …

Genome-wide association studies (GWAS) have highlighted that almost any trait is affected
by many variants of relatively small effect. On one hand this presents a challenge for …

Human genetics has emerged as one of the most dynamic areas of biology, with a
broadening societal impact. In this review, we discuss recent achievements, ongoing efforts …

'The Apportionment of Human Diversity'stands as a noteworthy intervention, both for the field
of human population genetics as well as in the annals of public communication of science …