The identification of CD4+ T cells localizing to B cell follicles has revolutionized the
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …

CD4+ follicular helper T (Tfh) cells play a vital role in providing help for B cells undergoing
selection and differentiation into activated antibody-secreting cells in mammalian germinal …

CD4+ T cell-derived interleukin 21 (IL-21) sustains CD8+ T cell responses during chronic
viral infection, but the helper subset that confers this protection remains unclear. Here, we …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

The development and differentiation of T cells represents a long and highly coordinated, yet
flexible at some points, pathway, along which the sequential and dynamic expressions of …

Palatine tonsils are secondary lymphoid organs (SLOs) representing the first line of
immunological defense against inhaled or ingested pathogens. We generated an atlas of …

Mutational activation of KRAS is a common oncogenic event in lung cancer, yet effective
therapies are still lacking. Here, we identify B cell lymphoma 6 (BCL6) as a lynchpin in …

Mammalian innate lymphoid cells (ILCs) have functional relevance under both homeostatic
and disease settings, such as inflammatory bowel disease (IBD), particularly in the context of …

Objective: Systemic lupus erythematosus (SLE) is a chronic and complex autoimmune
disease characterized by multiple autoantibodies, resulting in multiple organ and tissue …

Most antibodies produced in the body are of the IgA class. The dominant cell population
producing them are plasma cells within the lamina propria of the gastrointestinal tract, but …