Use of the CRISPR/Cas9 system to produce genetically engineered pigs from in vitro-derived oocytes and embryos
KM Whitworth, K Lee, JA Benne, BP Beaton… - Biology of …, 2014 - academic.oup.com
Targeted modification of the pig genome can be challenging. Recent applications of the
CRISPR/Cas9 system hold promise for improving the efficacy of genome editing. When a …
CRISPR/Cas9 system hold promise for improving the efficacy of genome editing. When a …
Production of Pigs From Porcine Embryos Generated in vitro
PR Chen, K Uh, BK Redel, ED Reese… - Frontiers in Animal …, 2022 - frontiersin.org
Generating porcine embryos in vitro is a critical process for creating genetically modified
pigs as agricultural and biomedical models; however, these embryo technologies have been …
pigs as agricultural and biomedical models; however, these embryo technologies have been …
Rodent Models of Huntington's Disease: An Overview
Huntington's disease (HD) is an autosomal-dominant inherited neurological disorder caused
by a genetic mutation in the IT15 gene. This neurodegenerative disorder is caused by a …
by a genetic mutation in the IT15 gene. This neurodegenerative disorder is caused by a …
Production of CFTR-null and CFTR-ΔF508 heterozygous pigs by adeno-associated virus–mediated gene targeting and somatic cell nuclear transfer
CS Rogers, Y Hao, T Rokhlina… - The Journal of …, 2008 - Am Soc Clin Investig
Progress toward understanding the pathogenesis of cystic fibrosis (CF) and developing
effective therapies has been hampered by lack of a relevant animal model. CF mice fail to …
effective therapies has been hampered by lack of a relevant animal model. CF mice fail to …
Generation of human endothelium in pig embryos deficient in ETV2
The scarcity of donor organs may be addressed in the future by using pigs to grow
humanized organs with lower potential for immunological rejection after transplantation in …
humanized organs with lower potential for immunological rejection after transplantation in …
Significant improvement in cloning efficiency of an inbred miniature pig by histone deacetylase inhibitor treatment after somatic cell nuclear transfer
Abstract The National Institutes of Health (NIH) miniature pig was developed specifically for
xenotransplantation and has been extensively used as a large-animal model in many other …
xenotransplantation and has been extensively used as a large-animal model in many other …
Coordination of zygotic genome activation entry and exit by H3K4me3 and H3K27me3 in porcine early embryos
G Bu, W Zhu, X Liu, J Zhang, L Yu, K Zhou… - Genome …, 2022 - genome.cshlp.org
Histone modifications are critical epigenetic indicators of chromatin state associated with
gene expression. Although the reprogramming patterns of H3K4me3 and H3K27me3 have …
gene expression. Although the reprogramming patterns of H3K4me3 and H3K27me3 have …
A genetic porcine model of cancer
LB Schook, TV Collares, W Hu, Y Liang, FM Rodrigues… - PloS one, 2015 - journals.plos.org
The large size of the pig and its similarity in anatomy, physiology, metabolism, and genetics
to humans make it an ideal platform to develop a genetically defined, large animal model of …
to humans make it an ideal platform to develop a genetically defined, large animal model of …
Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs
Neurodegeneration is a hallmark of many neurological diseases, including Alzheimer's,
Parkinson's and the polyglutamine diseases, which are all caused by misfolded proteins that …
Parkinson's and the polyglutamine diseases, which are all caused by misfolded proteins that …
[HTML][HTML] Generation of an inbred miniature pig model of retinitis pigmentosa
Purpose.: The Pro23His (P23H) rhodopsin (RHO) mutation underlies the most common form
of human autosomal dominant retinitis pigmentosa (adRP). The objective of this …
of human autosomal dominant retinitis pigmentosa (adRP). The objective of this …