Metformin is the oldest and most commonly used first-line antidiabetic drug because of its
good clinical efficacy, high safety, low cost and easy access. At the same time, in recent …

Increasing evidence suggests that the failure of clinical antidepressants may be related with
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …

Omega-3 polyunsaturated fatty acids (PUFAs) can play important roles in maintaining
mental health and resistance to stress, and omega-3 PUFAs supplementation can display …

Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …

Curcumin is the major biologically active polyphenolic constituent in the turmeric plant
(Curcuma longa) that has been shown to have antioxidant, anti-inflammatory …

Depression is one of the key conditions addressed by the Mental Health Gap Action
Programme (mhGAP) of WHO that can lead to self-harm and suicide. Depression is …

The role of gut dysbiosis in depression is well established. However, recent studies have
shown that gut microbiota is regulated by intestinal epithelial cell (IEC) mitochondria, which …

Background Disrupted cellular communication, inflammatory responses and mitochondrial
dysfunction are consistently observed in late-life depression (LLD). Exosomes (EXs) …

Several lines of evidence have highlighted the crucial role of mitochondria-based therapy in
depression. However, there are still less mitochondrial targets for the depression treatment …

Molecular autism research is evolving toward a biopsychosocial framework that is more
informed by autistic experiences. In this context, research aims are moving away from …