Wnt signaling plays a central regulatory role across a remarkably diverse range of functions
during embryonic development, including those involved in the formation of bone and …

Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals
provided by the local hippocampal microenvironment support neural stem cell proliferation …

Wnt signaling is crucial for embryonic development in all animal species studied to date. The
interaction between Wnt proteins and cell surface receptors can result in a variety of …

The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that
regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural …

The smoothened (SMO) receptor, a key signal transducer in the hedgehog signalling
pathway, is responsible for the maintenance of normal embryonic development and is …

Single nucleotide polymorphism (SNP) is the simplest form of DNA variation among
individuals. These simple changes can be of transition or transversion type and they occur …

Drosophila olfactory sensory neurons (OSNs) each express two odorant receptors (ORs): a
divergent member of the OR family and the highly conserved, broadly expressed receptor …

The oncoprotein Smoothened (SMO), a G-protein-coupled receptor (GPCR) of the Frizzled-
class (class-F), transduces the Hedgehog signal from the tumour suppressor Patched-1 …

Purpose: Wnt signaling is implicated in tumor cell dedifferentiation and cancer stem cell
function. Ipafricept (OMP-54F28) is a first-in-class recombinant fusion protein with the …

The Wnt signaling pathways are a group of signal transduction pathways that play an
important role in cell fate specification, cell proliferation and cell migration. Aberrant …