[HTML][HTML] Quantitative imaging biomarkers in age-related macular degeneration and diabetic eye disease: a step closer to precision medicine

G Kalra, SS Kar, DD Sevgi, A Madabhushi… - Journal of Personalized …, 2021 - mdpi.com
The management of retinal diseases relies heavily on digital imaging data, including optical
coherence tomography (OCT) and fluorescein angiography (FA). Targeted feature extraction …

Predictors of visual acuity after treatment of neovascular age-related macular degeneration–current perspectives

LT Phan, GK Broadhead, TH Hong… - Clinical …, 2021 - Taylor & Francis
Visual acuity is a key outcome measure in the treatment of neovascular age-related macular
degeneration (nAMD) using anti-vascular endothelial growth factor agents. Large variations …

[HTML][HTML] Predicting treat-and-extend outcomes and treatment intervals in neovascular age-related macular degeneration from retinal optical coherence tomography …

H Bogunović, V Mares, GS Reiter… - Frontiers in …, 2022 - frontiersin.org
Purpose To predict visual outcomes and treatment needs in a treat & extend (T&E) regimen
in neovascular age-related macular degeneration (nAMD) using a machine learning model …

[HTML][HTML] Longitudinal quantitative ultrawide-field fluorescein angiography dynamics in the RUBY diabetic macular edema study

K Sarici, S Yordi, A Martin, L Lunasco, C Mugnaini… - Ophthalmology …, 2023 - Elsevier
Objective The purpose of this study was to evaluate the longitudinal change in quantitative
ultrawide-field angiographic (UWFA) parameters and correlate them with functional …

[HTML][HTML] Machine learning-based automated detection and quantification of geographic atrophy and hypertransmission defects using spectral domain optical …

G Kalra, H Cetin, J Whitney, S Yordi, Y Cakir… - Journal of Personalized …, 2022 - mdpi.com
The current study describes the development and assessment of innovative, machine
learning (ML)-based approaches for automated detection and pixel-accurate measurements …

[HTML][HTML] Prognostic optical coherence tomography biomarkers in neovascular age-related macular degeneration

B Nawash, J Ong, M Driban, J Hwang, J Chen… - Journal of Clinical …, 2023 - mdpi.com
Optical coherence tomography has revolutionized the diagnosis and management of
neovascular age-related macular degeneration. OCT-derived biomarkers have the potential …

Deep-learning-based automated measurement of outer retinal layer thickness for use in the assessment of age-related macular degeneration, applicable to both …

J Lu, Y Cheng, FE Hiya, M Shen, G Herrera… - Biomedical optics …, 2023 - opg.optica.org
Effective biomarkers are required for assessing the progression of age-related macular
degeneration (AMD), a prevalent and progressive eye disease. This paper presents a deep …

Volume electron microscopy reveals human retinal mitochondria that align with reflective bands in optical coherence tomography

D Kar, YJ Kim, O Packer, ME Clark, D Cao… - Biomedical Optics …, 2023 - opg.optica.org
Mitochondria are candidate reflectivity signal sources in optical coherence tomography
(OCT) retinal imaging. Here, we use deep-learning-assisted volume electron microscopy of …

[HTML][HTML] Potential structural biomarkers in 3D images validated by the first functional biomarker for early age-related macular degeneration–ALSTAR2 Baseline

S Fasih-Ahmad, Z Wang, Z Mishra… - … & Visual Science, 2024 - tvst.arvojournals.org
Purpose: Lack of valid end points impedes developing therapeutic strategies for early age-
related macular degeneration (AMD). Delayed rod-mediated dark adaptation (RMDA) is the …

Machine learning–based automated detection of hydroxychloroquine toxicity and prediction of future toxicity using higher-order OCT biomarkers

G Kalra, KE Talcott, S Kaiser, O Ugwuegbu, M Hu… - Ophthalmology …, 2022 - Elsevier
Objective Despite guidelines for hydroxychloroquine (HCQ) toxicity screening, there are
clear challenges to accurate detection and interpretation. In the current report, the feasibility …