The present invention relates generally to synthetic genes for modifying endogenous gene
expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic …

Post-transcriptional gene silencing (PTGS) is a homology-dependent process that reduces
cytoplasmic RNA levels. In several experimental systems, there is also an association of …

Post-transcriptional gene silencing (PTGS) in plants is an RNA-degradation mechanism that
shows similarities to RNA interference (RNAi) in animals. Indeed, both involve double …

By capitalizing on the initially puzzling observations of unpredictable transgene silencing
and variable expression, plant scientists have pioneered research into a novel type of …

Double-stranded RNA (dsRNA) has been shown to play a key role as an inducer of different
interference phenomena occurring in both the plant and animal kingdoms. Here, we show …

Increasing evidence supports the idea that various transgene silencing phenomena reflect
the activity of diverse host defense responses that act ordinarily on natural foreign or …

▪ Abstract Epigenetic silencing of transgenes and endogenous genes can occur at the
transcriptional level (TGS) or at the posttranscriptional level (PTGS). Because they can be …

RNA silencing occurs in a wide variety of organisms, including protozoa, fungi, plants and
animals and involves recognition of a target RNA and initiation of a sequence-specific RNA …

Several milestones in biology have been achieved since the first publication of the
Handbook of Molecular and Cellular Methods in Biology and Medicine. This is true …

Plant virus‐based vectors carrying sequences homologous to endogenous genes trigger
silencing through a homology‐dependent RNA degradation mechanism. This phenomenon …