HIV-1/AIDS remains a global public health problem. The world health organization (WHO)
reported at the end of 2019 that 38 million people were living with HIV-1 worldwide, of which …

The most studied HIV eradication approach is the “shock and kill” strategy, which aims to
reactivate the latent reservoir by latency reversing agents (LRAs) and allowing elimination of …

The HIV-1 latent reservoir is established early after infection, persists during antiretroviral
therapy, and is the source of viral rebound after treatment interruption. An HIV cure requires …

Expression of the HIV-1 genome by RNA Polymerase II is regulated at multiple steps, as are
most cellular genes, including recruitment of general transcription factors and control of …

The existence of latent cellular reservoirs is recognized as the major barrier to an HIV cure.
Reactivating and eliminating “shock and kill” or permanently silencing “block and lock” the …

The total synthesis and biological evaluation of the marine sesterterpenoid ansellone A (1),
an HIV latency-reversing agent, and its analogues are reported. The key to the success of …

The emergence of drug-resistant Human Immunodeficiency Virus-1 strains against anti-HIV
therapies in the clinical pipeline, and the persistence of HIV in cellular reservoirs remains a …

Structurally simplified analogues of ansellone A, in which the decalin skeleton is replaced
with a lipophilic chain, were prepared and their HIV latency‐reversing activities biologically …

The first total synthesis of marine sesterterpenoid ansellone G (2) was accomplished. This
strategy utilizes the Prins cyclization reaction of a chloro-substituted homoallyl alcohol to …

Current antiretroviral therapy for HIV-1 infection does not represent a cure for infection as
viral rebound inevitably occurs following discontinuation of treatment. The “block and lock” …