Macrophages as tools and targets in cancer therapy

A Mantovani, P Allavena, F Marchesi… - Nature Reviews Drug …, 2022 - nature.com
Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

Hallmarks of cancer: new dimensions

D Hanahan - Cancer discovery, 2022 - AACR
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity
of cancer phenotypes and genotypes into a provisional set of underlying principles. As …

A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors

AB Dohlman, J Klug, M Mesko, IH Gao, SM Lipkin… - Cell, 2022 - cell.com
Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the
human microbiome, yet little is known about their role in human cancers. Pan-cancer …

Targeting the gut microbiota for cancer therapy

MR Fernandes, P Aggarwal, RGF Costa… - Nature Reviews …, 2022 - nature.com
Growing evidence suggests that the gut microbiota modulates the efficacy and toxicity of
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …

Immunology and immunotherapy of cholangiocarcinoma

TF Greten, R Schwabe, N Bardeesy, L Ma… - Nature Reviews …, 2023 - nature.com
Cholangiocarcinoma is the second most common primary liver cancer. Its incidence is low in
the Western world but is rising globally. Surgery, chemotherapy and radiation therapy have …

Activity‐based NIR enzyme fluorescent probes for the diagnosis of tumors and image‐guided surgery

H Li, D Kim, Q Yao, H Ge, J Chung, J Fan… - Angewandte …, 2021 - Wiley Online Library
Near‐infrared (NIR) activatable fluorescent probes have been considered to be the effective
edge tools for the investigation of cell biology and disease diagnosis because of their …

[HTML][HTML] Commensal microbiota promote lung cancer development via γδ T cells

C Jin, GK Lagoudas, C Zhao, S Bullman, A Bhutkar… - Cell, 2019 - cell.com
Lung cancer is closely associated with chronic inflammation, but the causes of inflammation
and the specific immune mediators have not been fully elucidated. The lung is a mucosal …

NF-κB, inflammation, immunity and cancer: coming of age

K Taniguchi, M Karin - Nature Reviews Immunology, 2018 - nature.com
Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a
molecular lynchpin that links persistent infections and chronic inflammation to increased …

The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells

NN Liu, CX Yi, LQ Wei, JA Zhou, T Jiang, CC Hu… - Cancer Cell, 2023 - cell.com
Although polymorphic microbiomes have emerged as hallmarks of cancer, far less is known
about the role of the intratumor mycobiome as living microorganisms in cancer progression …

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

R Singh, S Chandrashekharappa, SR Bodduluri… - Nature …, 2019 - nature.com
The importance of gut microbiota in human health and pathophysiology is undisputable.
Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in …