Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter
CA Stockmeier - Journal of psychiatric research, 2003 - Elsevier
Definitive conclusions on the role of serotonin receptors and transporter in suicide and
depression have been elusive in studies of postmortem brain tissue. A number of …
depression have been elusive in studies of postmortem brain tissue. A number of …
Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain
D Marazziti, L Palego, A Giromella… - International Journal …, 2002 - academic.oup.com
The mode of action of antidepressant drugs may be related to mechanisms of receptor
adaptation, involving overall the serotonin 1A (5-HT1A) receptor subtype. However, so far …
adaptation, involving overall the serotonin 1A (5-HT1A) receptor subtype. However, so far …
Combined serotonin (5-HT) 1A agonism, 5-HT2A and dopamine D2 receptor antagonism reproduces atypical antipsychotic drug effects on phencyclidine-impaired …
Y Oyamada, M Horiguchi, L Rajagopal… - Behavioural Brain …, 2015 - Elsevier
Subchronic administration of an N-methyl-d-aspartate receptor (NMDAR) antagonist, eg
phencyclidine (PCP), produces prolonged impairment of novel object recognition (NOR) …
phencyclidine (PCP), produces prolonged impairment of novel object recognition (NOR) …
Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder
CA Stockmeier, E Howley, X Shi, A Sobanska… - Journal of psychiatric …, 2009 - Elsevier
Serotonin-1A receptors may play a role in the pathophysiology of depression and suicide. In
postmortem brain tissue, agonist binding to serotonin-1A receptors is reportedly increased …
postmortem brain tissue, agonist binding to serotonin-1A receptors is reportedly increased …
Apparent absence of aging and gender effects on serotonin 1A receptors in human neocortex and hippocampus
L Palego, D Marazziti, A Rossi, G Giannaccini… - Brain research, 1997 - Elsevier
The effects of gender, aging and gender× age on the binding of the 5-HT1A receptor high-
affinity agonist [3H] 8-hydroxy-2 (di-N-propylamino) tetralin ([3H] 8-OH-DPAT), were …
affinity agonist [3H] 8-hydroxy-2 (di-N-propylamino) tetralin ([3H] 8-OH-DPAT), were …
Effects of postmortem delay on serotonin and (+) 8-OH-DPAT-mediated inhibition of adenylyl cyclase activity in rat and human brain tissues
L Palego, A Giromella, D Marazziti, F Borsini… - Brain research, 1999 - Elsevier
The reproducibility of serotonin (5-HT) and (+) 8-OH-DPAT-mediated inhibition of adenylyl
cyclase activity was assessed in membranes, stimulated by forskolin, of rat frontal cortex …
cyclase activity was assessed in membranes, stimulated by forskolin, of rat frontal cortex …
Mechanisms governing the differentiation of a serotonergic phenotype in culture
J Zhou, L Iacovitti - Brain research, 2000 - Elsevier
In this study, we explored whether a serotonergic (5-HT) phenotype could be novelly
induced in the phenotypically plastic neurons of the developing striatum. We found that the 5 …
induced in the phenotypically plastic neurons of the developing striatum. We found that the 5 …
Lack of stereoselectivity of 8-hydroxy-2 (di-N-propylamino) tetralin-mediated inhibition of forskolin-stimulated adenylyl cyclase activity in human pre-and post-synaptic …
L Palego, A Giromella, D Marazziti… - Neurochemistry …, 2000 - Elsevier
The stereoselectivity of the serotonin1A (5-HT1A) receptor compound 8-hydroxy-2 (di-N-
propylamino) tetralin (8-OH-DPAT) on forskolin-stimulated adenylyl cyclase activity was …
propylamino) tetralin (8-OH-DPAT) on forskolin-stimulated adenylyl cyclase activity was …
Short-term effects of 3, 4-methylen-dioxy-metamphetamine (MDMA) on 5-HT1A receptors in the rat hippocampus
G Giannaccini, L Betti, A Pirone, L Palego… - Neurochemistry …, 2007 - Elsevier
The first effects of 3, 4-methylen-dioxy-metamphetamine (MDMA,“ecstasy”), on serotonin 1A
(5-HT1A) receptors in rat hippocampus were determined by means of [3H]-8-hydroxy …
(5-HT1A) receptors in rat hippocampus were determined by means of [3H]-8-hydroxy …
WAY‐100635 antagonist‐induced plasticity of 5‐HT1A receptors: regulatory differences between a stable cell line and an in vivo native system
XZ Khawaja, DL Smith, SP Nawoschik… - Journal of …, 2006 - Wiley Online Library
We present evidence that the 5‐hydroxytryptamine1A (5‐HT1A) receptor antagonist, N‐{2‐[4‐
(2‐methoxyphenyl)‐1‐piperazinyl]‐ethyl}‐N‐(2‐pyridinyl) cyclohexanecarboxamide (WAY …
(2‐methoxyphenyl)‐1‐piperazinyl]‐ethyl}‐N‐(2‐pyridinyl) cyclohexanecarboxamide (WAY …