Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum
Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …
disorders characterized by early-onset, often severe epileptic seizures and EEG …
[HTML][HTML] Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles
NR Tykocki, EM Boerman… - Comprehensive Physiology, 2017 - ncbi.nlm.nih.gov
Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
Ion channels in genetic epilepsy: from genes and mechanisms to disease-targeted therapies
J Oyrer, S Maljevic, IE Scheffer, SF Berkovic… - Pharmacological …, 2018 - ASPET
Epilepsy is a common and serious neurologic disease with a strong genetic component.
Genetic studies have identified an increasing collection of disease-causing genes. The …
Genetic studies have identified an increasing collection of disease-causing genes. The …
Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function
S Erdogmus, AR Concepcion, M Yamashita… - Nature …, 2022 - nature.com
TCR stimulation triggers Ca2+ signals that are critical for T cell function and immunity.
Several pore-forming α and auxiliary β subunits of voltage-gated Ca2+ channels (VGCC) …
Several pore-forming α and auxiliary β subunits of voltage-gated Ca2+ channels (VGCC) …
Genetic associations between voltage-gated calcium channels and psychiatric disorders
Psychiatric disorders are mental, behavioral or emotional disorders. These conditions are
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …
Antihypertensive drugs and brain function: mechanisms underlying therapeutically beneficial and harmful neuropsychiatric effects
C Carnovale, C Perrotta, S Baldelli… - Cardiovascular …, 2023 - academic.oup.com
A bidirectional relationship exists between hypertension and psychiatric disorders, including
unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis …
unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis …
Calcium signals during SARS-CoV-2 infection: Assessing the potential of emerging therapies
S Berlansky, M Sallinger, H Grabmayr, C Humer… - Cells, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-
stranded RNA virus that causes coronavirus disease 2019 (COVID-19). This respiratory …
stranded RNA virus that causes coronavirus disease 2019 (COVID-19). This respiratory …
L-type calcium channel blockers: a potential novel therapeutic approach to drug dependence
HJ Little - Pharmacological Reviews, 2021 - ASPET
This review describes interactions between compounds, primarily dihydropyridines, that
block L-type calcium channels and drugs that cause dependence, and the potential …
block L-type calcium channels and drugs that cause dependence, and the potential …
Target molecules of STIM proteins in the central nervous system
K Serwach, J Gruszczynska-Biegala - Frontiers in molecular …, 2020 - frontiersin.org
Stromal interaction molecules (STIMs), including STIM1 and STIM2, are single-pass
transmembrane proteins that are located predominantly in the endoplasmic reticulum (ER) …
transmembrane proteins that are located predominantly in the endoplasmic reticulum (ER) …
Two transcriptionally distinct pathways drive female development in a reptile with both genetic and temperature dependent sex determination
How temperature determines sex remains unknown. A recent hypothesis proposes that
conserved cellular mechanisms (calcium and redox;'CaRe'status) sense temperature and …
conserved cellular mechanisms (calcium and redox;'CaRe'status) sense temperature and …