Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …

The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants
and “anatomical escape” characteristics threaten the effectiveness of current coronavirus …

Inflammation must be tightly regulated to both defend against pathogens and restore tissue
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …

Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …

In their recent publication, Wang et al. propose that influenza infection in the lungs confers
resistance to metastatic tumor growth due to trained immunity in the alveolar macrophage …

Emerging and re-emerging respiratory viral infections pose a tremendous threat to human
society, as exemplified by the ongoing COVID-19 pandemic. Upon viral invasion of the …

Aging impairs the immune responses to influenza A virus (IAV), resulting in increased
mortality to IAV infections in older adults. However, the factors within the aged lung that …

Influenza A virus (IAV) infection mobilizes bone marrow-derived macrophages (BMDM) that
gradually undergo transition to tissue-resident alveolar macrophages (TR-AM) in the …

Sepsis induces immune alterations, which last for months after the resolution of illness. The
effect of this immunological reprogramming on the risk of developing cancer is unclear. Here …