Abstract Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …

Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

The accumulation of senescent cells is a major cause of age-related inflammation and
predisposes to a variety of age-related diseases. However, little is known about the …

Conclusions: Our study sheds light on the pivotal role of METTL1 in modulating an
immunosuppressive microenvironment and demonstrated that interrupting METTL1‐TGF‐β2 …

Cancer cells rewire metabolism to favour the generation of specialized metabolites that
support tumour growth and reshape the tumour microenvironment,. Lysine functions as a …

Summary Cyclic GMP-AMP synthase (cGAS) is the major sensor for cytosolic DNA and
activates type I interferon signaling and plays an essential role in antitumor immunity …

Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies.
Emerging evidence suggests that certain epigenetic and transcriptional regulators drive …

The development and immune evasion of cancer stem cells (CSCs) limit the efficacy of
currently available anticancer therapies. Recent studies have shown that epigenetic …

In eukaryotes, repetitive DNA sequences are transcriptionally silenced through histone H3
lysine 9 trimethylation (H3K9me3). Loss of silencing of the repeat elements leads to genome …

Recurrence of advanced melanoma after therapy is a major risk factor for reduced survival,
and treatment options are limited. Antitumor immune memory plays a critical role in …