Compelling evidence for the inherited nature of essential hypertension has led to extensive
research in rats and humans. Rats have served as the primary model for research on the …

Background The aldosterone synthase gene (CYP1B2) locus is a candidate region involved
in the development of hypertension. Objective To study the relationship between the C-344T …

Objective The CYP11B2 locus is an important candidate region in essential hypertension
(HT). We therefore investigated CYP11B2 polymorphisms T− 344C, T4986C and A6547G …

Chronic heart failure (CHF) is a common disease with high associated morbidity and
mortality, and the outcome appears to be worse in black compared with white patients …

OBJECTIVES This study examined the association between the− 344 C/T polymorphism of
the human aldosterone synthase promoter and left ventricular structure in arterial …

Previously we reported that there is a blood pressure quantitative trait locus (QTL) on rat
Chromosome (Chr) 7 seen when comparing Dahl salt-sensitive (S) rats and Dahl salt …

Purpose In rats, chronic aldosterone administration with high diet intake increases aortic
stiffness independent of mechanical stress. In hypertensive humans, enhanced plasma …

No consensus view has been published on the relationship between the aldosterone
synthase gene (CYP11B2)− 344C/T polymorphism and left ventricular hypertrophy (LVH) in …

Objective Several recent studies have shown that the aldosterone synthase gene
(CYP11B2)− 344C/T polymorphism is related to cardiovascular diseases. However, whether …

Aldosterone synthase is a key enzyme in aldosterone production. Polymorphisms of the
aldosterone synthase gene, CYP11B2, have been suggested to be involved in the …