Malignant brain tumors, a heterogeneous group of primary and metastatic neoplasms in the
central nervous system (CNS), are notorious for their highly invasive and devastating …

Background Cuproptosis is a newly discovered unique non-apoptotic programmed cell
death distinguished from known death mechanisms like ferroptosis, pyroptosis, and …

Effective drug delivery and prevention of postoperative recurrence are significant challenges
for current glioblastoma (GBM) treatment. Poor drug delivery is mainly due to the presence …

Rationale: Accumulating evidence demonstrated that long noncoding RNAs (lncRNAs)
involved in the regulation of the immune system and displayed a cell-type-specific pattern in …

Long noncoding ribonucleic acids (RNAs; lncRNAs) have been associated with cancer
immunity regulation. However, the roles of immune cell-specific lncRNAs in glioblastoma …

Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing
technology represents a significant breakthrough in personalized immunotherapy for human …

Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages.
Although there are few therapeutic options for brain tumors, enhanced biological …

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, while its
frequency in pediatric patients is 10–15%. For this reason, age is considered one of the …

Small extracellular vesicles (SEVs) are extracellular vesicles containing DNA, RNA, and
proteins and are involved in intercellular communication and function, playing an essential …

Increasing evidence suggests that besides mutational and molecular alterations, the
immune component of the tumor microenvironment also substantially impacts tumor …