Background. Growth hormone (GH) and insulin‐like growth factor (IGF‐1) are fundamental
in skeletal growth during puberty and bone health throughout life. GH increases tissue …

Abstract GH and IGF-I are important regulators of bone homeostasis and are central to the
achievement of normal longitudinal bone growth and bone mass. Although GH may act …

Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in
response to the endocrine GH stimulus, but it is also secreted by multiple tissues for …

I. Introduction G ROWTH hormone and the insulin-like growth factors (IGFs) compile a
complex, interrelated system of three peptide hormones, GH, IGF-I, and IGF-II, their specific …

Strenuously exercising young women with hypothalamic amenorrhea are hypoleptinemic
and have low bone mineral density (BMD) and content (BMC), which predispose them to …

Many of the diseases treated by orthopaedic surgeons reflect a failure of the function of
specific populations of cells. Skeletal deformities often stem directly or indirectly from the …

The growth hormone/insulin-like growth factor (GH/IGF) axis is critically important for the
regulation of bone formation, and deficiencies in this system have been shown to contribute …

Injections with growth hormone (GH) or insulin-like growth factor I (IGF-I) have been
proposed for anabolic therapy in osteoporosis. In a cross-over study, 12 men with idiopathic …

Insulin-like growth factor (IGF-1) is a polypeptide of 70 amino acids. The circulatory form of
IGF-1 is synthesised in the liver. The metabolic activity of IGF-1 is regulated by 6 IGF-binding …

Osteoporosis is the result of imbalance in bone remodeling caused by increased bone
resorption and decreased bone formation. In terms of the mechanisms for the age-related …