The role of vasculature and angiogenesis in respiratory diseases

M Ackermann, C Werlein, E Plucinski, S Leypold… - Angiogenesis, 2024 - Springer
In European countries, nearly 10% of all hospital admissions are related to respiratory
diseases, mainly chronic life-threatening diseases such as COPD, pulmonary hypertension …

CX3CL1 (Fractalkine)-CX3CR1 Axis in Inflammation-Induced Angiogenesis and Tumorigenesis

D Szukiewicz - International journal of molecular sciences, 2024 - mdpi.com
The chemotactic cytokine fractalkine (FKN, chemokine CX3CL1) has unique properties
resulting from the combination of chemoattractants and adhesion molecules. The soluble …

Vascular organs-on-chip made with patient-derived endothelial cells: technologies to transform drug discovery and disease modeling

CP Whitworth, WJ Polacheck - Expert Opinion on Drug Discovery, 2024 - Taylor & Francis
Introduction Vascular diseases impart a tremendous burden on healthcare systems in the
United States and across the world. Efforts to improve therapeutic interventions are hindered …

Human Cord Blood Endothelial Progenitor Cells and Pregnancy Complications (Preeclampsia, Gestational Diabetes Mellitus, and Fetal Growth Restriction)

JY Kwon, YS Maeng - International Journal of Molecular Sciences, 2024 - mdpi.com
Hemangioblasts give rise to endothelial progenitor cells (EPCs), which also express the cell
surface markers CD133 and c-kit. They may differentiate into the outgrowth endothelial cells …

Inflammatory risk contributes to post-COVID endothelial dysfunction through anti-ACKR1 autoantibody

ES Lee, N Nguyen, BE Young, H Wee… - Life Science …, 2024 - life-science-alliance.org
Subclinical vascular impairment can be exacerbated in individuals who experience
sustained inflammation after COVID-19 infection. Our study explores the prevalence and …

Transcriptional signatures of cortical structural changes in chronic insomnia disorder

L Yu, D Hu, Y Luo, W Lin, H Xu, X Xiao, Z Xia… - …, 2024 - Wiley Online Library
Chronic insomnia disorder (CID) is a multidimensional disease that may influence various
levels of brain organization, spanning the macroscopic structural connectome to microscopic …

Atorvastatin inhibits Lipopolysaccharide (LPS)-induced vascular inflammation to protect endothelium by inducing Heme Oxygenase-1 (HO-1) expression

J Luo, Q Zhu, K Huang, X Wen, Y Peng, G Chen, G Wei - Plos one, 2024 - journals.plos.org
Purpose This study aimed to explore the differential effects of varying doses of atorvastatin
on antagonizing lipopolysaccharide (LPS)-induced endothelial inflammation based on …