[HTML][HTML] Respiratory syncytial virus vaccines: a review of the candidates and the approved vaccines
X Topalidou, AM Kalergis, G Papazisis - Pathogens, 2023 - mdpi.com
Respiratory syncytial virus (RSV) is responsible for a significant proportion of global
morbidity and mortality affecting young children and older adults. In the aftermath of formalin …
morbidity and mortality affecting young children and older adults. In the aftermath of formalin …
[HTML][HTML] Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models …
AS Espeseth, PJ Cejas, MP Citron, D Wang… - npj Vaccines, 2020 - nature.com
Abstract The RSV Fusion (F) protein is a target for neutralizing antibody responses and is a
focus for vaccine discovery; however, the process of RSV entry requires F to adopt a …
focus for vaccine discovery; however, the process of RSV entry requires F to adopt a …
[HTML][HTML] New insights on respiratory syncytial virus prevention
E Kopera, H Czajka, P Zapolnik, A Mazur - Vaccines, 2023 - mdpi.com
Respiratory syncytial virus (RSV) is a well-known infant pathogen transmitted mainly by
droplets. It is a leading cause of upper respiratory tract infections in children, usually with a …
droplets. It is a leading cause of upper respiratory tract infections in children, usually with a …
[HTML][HTML] Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates
Respiratory syncytial virus (RSV) infection is a major cause of respiratory illness in infants
and the elderly. Although several vaccines have been developed, none have succeeded in …
and the elderly. Although several vaccines have been developed, none have succeeded in …
[HTML][HTML] Profiling of hMPV F-specific antibodies isolated from human memory B cells
Human metapneumovirus (hMPV) belongs to the Pneumoviridae family and is closely
related to respiratory syncytial virus (RSV). The surface fusion (F) glycoprotein mediates viral …
related to respiratory syncytial virus (RSV). The surface fusion (F) glycoprotein mediates viral …
Split-dose administration enhances immune responses elicited by a mRNA/lipid nanoparticle vaccine expressing respiratory syncytial virus F protein
mRNA vaccines have recently received significant attention due to their role in combating
the SARS-CoV-2 pandemic. As a platform, mRNA vaccines have been shown to elicit strong …
the SARS-CoV-2 pandemic. As a platform, mRNA vaccines have been shown to elicit strong …
[HTML][HTML] Engineered dityrosine-bonding of the RSV prefusion F protein imparts stability and potency advantages
SV Gidwani, D Brahmbhatt, A Zomback… - Nature …, 2024 - nature.com
Viral fusion proteins facilitate cellular infection by fusing viral and cellular membranes, which
involves dramatic transitions from their pre-to postfusion conformations. These proteins are …
involves dramatic transitions from their pre-to postfusion conformations. These proteins are …
[HTML][HTML] Virus-like particles containing a prefusion-stabilized F protein induce a balanced immune response and confer protection against respiratory syncytial virus …
J Luo, H Qin, L Lei, W Lou, R Li, Z Pan - Frontiers in Immunology, 2022 - frontiersin.org
Respiratory syncytial virus (RSV) is a serious respiratory pathogen in infants and young
children worldwide. Currently, no licensed RSV vaccines are available. In this study, we …
children worldwide. Currently, no licensed RSV vaccines are available. In this study, we …
[HTML][HTML] Crystal structure and immunogenicity of the DS-Cav1-stabilized fusion glycoprotein from respiratory syncytial virus subtype B
MG Joyce, A Bao, M Chen, IS Georgiev… - Pathogens and …, 2019 - ncbi.nlm.nih.gov
Background: Respiratory syncytial virus (RSV) subtypes, A and B, co-circulate in annual
epidemics and alternate in dominance. We have shown that a subtype A RSV fusion (F) …
epidemics and alternate in dominance. We have shown that a subtype A RSV fusion (F) …
Respiratory syncytial virus subunit vaccines based on the viral envelope glycoproteins intended for pregnant women and the elderly
M Beugeling, J De Zee, HJ Woerdenbag… - Expert review of …, 2019 - Taylor & Francis
Introduction: Respiratory syncytial virus (RSV) causes high morbidity and mortality rates
among infants, young children, and the elderly worldwide. Unfortunately, a safe and effective …
among infants, young children, and the elderly worldwide. Unfortunately, a safe and effective …